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In recent years, the number of intravenous infusion reactions has been increasing with the wide application of mannatide in clinical practice. In the present study, 38 cases of mannatide-induced infusion reactions reported in a single medical center from 2017 to 2021 were retrospectively analyzed. Moreover, independent high-risk factors for severe infusion reactions were assessed by the Chi-square test. The results showed that infusion reactions caused by mannatide mainly occurred in patients over 50 years old (71.05%) and primarily occurred within 10 min of drug administration (86.84%), and patients with underlying diseases or drug allergies suffered from severe infusion reactions caused by mannatide. Therefore, the patients with advanced age, previous history of drug allergy, basic medical history, and the first use of this drug, especially within 10 min after administration, should be highly vigilant and closely monitored. [ABSTRACT FROM AUTHOR]