1. Relationships between structure and albumin-binding of amines tested with crossing-paper electrophoresis
- Author
-
D. Bovet and M.H. Bickel
- Subjects
Electrophoresis ,Paper ,Chemical structure ,Serum albumin ,chemistry.chemical_element ,Paper electrophoresis ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Albumins ,Organic chemistry ,Ammonium ,Electrophoresis, Paper ,Amines ,Serum Albumin ,Chromatography ,Primary (chemistry) ,Hematologic Tests ,biology ,Chemistry ,Organic Chemistry ,Albumin ,General Medicine ,Nitrogen ,biology.protein - Abstract
Some 75 nitrogen-containing substances have been screened with regard to their interaction with blood albumin by means of crossing-paper electrophoresis. The results show that there are definite relationships between the interaction and the chemical structure of the substances. Only tertiary amines with at least one substantial radical interact, whereas primary and secondary amines and quaternary ammonium salts do not. With mixed amines interaction only occurs if the tertiary nitrogen “dominates” the other amino groups.
- Published
- 1962