204 results on '"Hubbuch, Jürgen"'
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2. Antibody sequence-based prediction of pH gradient elution in multimodal chromatography
3. Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation
4. Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps
5. Steric exclusion chromatography of lentiviral vectors using hydrophilic cellulose membranes
6. Exploration of fiber-based cation exchange adsorbents for the removal of monoclonal antibody aggregates
7. Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model
8. Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach
9. High throughput screening of fiber-based adsorbents for material and process development
10. On the analysis of chromatographic biopharmaceutical data by curve resolution techniques in the framework of the area of feasible solutions
11. Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation
12. Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography
13. Prediction uncertainty assessment of chromatography models using Bayesian inference
14. Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment
15. Packing characteristics of winged shaped polymer fiber supports for preparative chromatography
16. In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography
17. An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration
18. Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks
19. Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure–activity relationship modeling approach
20. Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
21. Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks
22. An orientation sensitive approach in biomolecule interaction quantitative structure–activity relationship modeling and its application in ion-exchange chromatography
23. A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases
24. Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography
25. High-throughput downstream process development for cell-based products using aqueous two-phase systems
26. Quantification of PEGylated proteases with varying degree of conjugation in mixtures: An analytical protocol combining protein precipitation and capillary gel electrophoresis
27. Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography
28. Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles
29. Custom-tailored adsorbers: A molecular dynamics study on optimal design of ion exchange chromatography material
30. Light extinction and scattering by agarose based resin beads and applications in high-throughput screening
31. Influence of binding pH and protein solubility on the dynamic binding capacity in hydrophobic interaction chromatography
32. Downstream processing of virus-like particles: Single-stage and multi-stage aqueous two-phase extraction
33. A comprehensive molecular dynamics approach to protein retention modeling in ion exchange chromatography
34. Characterization of aqueous two phase systems by combining lab-on-a-chip technology with robotic liquid handling stations
35. Alternative separation steps for monoclonal antibody purification: Combination of centrifugal partitioning chromatography and precipitation
36. A high-throughput 2D-analytical technique to obtain single protein parameters from complex cell lysates for in silico process development of ion exchange chromatography
37. Analytical characterization of complex, biotechnological feedstocks by pH gradient ion exchange chromatography for purification process development
38. Self-interaction chromatography in pre-packed columns: A critical evaluation of self-interaction chromatography methodology to determine the second virial coefficient
39. Systematic generation of buffer systems for pH gradient ion exchange chromatography and their application
40. Isoform separation and binding site determination of mono-PEGylated lysozyme with pH gradient chromatography
41. Rapid quantification of protein–polyethylene glycol conjugates by multivariate evaluation of chromatographic data
42. High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies
43. A sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography
44. Effects of ionic strength and mobile phase pH on the binding orientation of lysozyme on different ion-exchange adsorbents
45. Comparison of chromatographic ion-exchange resins: VI. Weak anion-exchange resins
46. A novel two-zone protein uptake model for affinity chromatography and its application to the description of elution band profiles of proteins fused to a family 9 cellulose binding module affinity tag
47. A novel approach to characterize the binding orientation of lysozyme on ion-exchange resins
48. Investigation of pore diffusion hindrance of monoclonal antibody in hydrophobic interaction chromatography using confocal laser scanning microscopy
49. Developing a chromatographic column model for bovine serum albumin on strong anion-exchanger Source30Q using data from confocal laser scanning microscopy
50. Short-cut method for the correction of light attenuation influences in the experimental data obtained from confocal laser scanning microscopy
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