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The vast hydrocarbon resources (oil, gas, and gas hydrate) in deepwater areas are considered one of the most significant resources of the future. However, the dangerous flow patterns and blockage accidents caused by hydrates threaten the safety and efficiency of the transportation process. A mutual interaction exists between hydrate growth and multiphase flow. In this study, hydrate formation and gas–slurry two–phase flow tests were conducted in a pure water system with a constant pressure (4 MPa) and various liquid loadings (40–80%) in a visual flow loop. It was found that the hydrate growth process in the dynamic system included bubble promotion, subcooling promotion, and mass transfer inhibition. Meanwhile, two atypical slug patterns (rapid conversion slug and deposition slug) in the vertical upward flow were determined, which corresponded to the promotion and inhibition regions. In the rapid conversion slug flow, the churn segments replaced the original Taylor bubbles when the liquid loading was less than 60%. In the deposition slug flow, slurry shedding phenomena was observed. In addition, the hydrate particle deposition behavior was found to inhibit hydrate growth and cause flow pattern shifts, but did not trigger the differential pressure surge. The gas isolation caused by the liquid plug and energy dissipation due to the collision between hydrate particles and the tube wall may be responsible for the sudden increase in pressure drop. Furthermore, the feasibility of predicting hydrate blockage using the differential pressure method was explored. The experiment results showed that this warning method was effective when the liquid loading was below 76%. And an effective warning can improve the transport capacity by approximately 34%. • The hydrate formation and flow behaviors are complicated in deepwater risers. • Hydrate formation and multiphase flow behaviors were observed by a visual flow loop. • Three regions of growth kinetics and two atypical slug patterns were determined. • The differential-pressure hydrate blockage warning method was proposed. [ABSTRACT FROM AUTHOR]