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The concept of NZEB (Nearly Zero Energy Building) has a promising share to fulfill the future of sustainable development goals. However, exploiting renewable-based THESs (Trigeneration Hybrid Energy Systems) for providing the energetic demands of the building sector needs further attention. In this regard, the present paper proposes a sustainable THES driven by a biogas-fueled gas engine. The bottoming systems comprise absorption/electrical chillers (AC and EC), organic Rankine cycle (ORC), solar collector (PTC), and an auxiliary boiler. A detailed sustainability evaluation framework (technical and eco-environment) is derived to approve the performance of the THES. Within this procedure, the best working fluid of the ORC is firstly selected and then the sensitivity of the system performance to the design variables is assessed by a comprehensive parametric study. To make the derived framework more applicable, a case study building is considered and the proposed THES is sized to meet its electricity, heating, and cooling energies. The analyses proved that R123 shows the best techno-economic performance among six investigated ORC working fluids. The parametric study illustrated that the highest and lowest sensitivity of the THES's performance is related to the outlet temperatures of EC condenser and AC evaporator. Furthermore, the energy, exergy, and economic efficiencies of the THES for the case study building are 61.78%, 25.24%, and 44.77%. In this condition, discounted payback period is 7 years, demonstrating the feasibility of this proposal. The maximum CO 2 emission is released in November, with a total electricity generation of 320 MWh. [Display omitted] • Renewable-based hybrid system is introduced to produce cold, heat, and power. • Comprehensive sensitivity analysis is done to assess impact of some decision variables. • A case study building is considered to boost NZEB concept based on the proposed system. • Energy efficiency and payback period is 61.78% and 7 years for the case study building. • Using renewables in energy systems to reduce fossil fuel share has great significance. [ABSTRACT FROM AUTHOR]