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China has experienced serious environmental problems along with rapid economic development in recent years. Industrial production is the fundamental cause of Chinese environmental problems, while production is mainly managed and governed by local industrial Parks. Currently, Chinese industrial parks have just begun to think about sustainable development, and the demonstrative parks are designated as eco-industrial parks (EIPs); however, the EIPs' development strategies and targets are still vague and lack scientific guidance. Therefore, an optimal decision making approach can support EIPs to address environment problems and achieve regional economic development. This study provides an integrated approach to assess the multiple impacts of EIP development strategies and propose optimization planning by using a case study in Wuhu EIP. The initially constructed decision-making model systemically integrates the dynamic model of the Environment-Economic-Energy (3Es) system and an input-output model; then, the model is established and simulated using a linear optimization method. An optimal development strategy can be put forward by analysing scenarios for the Wuhu EIP. Based on the findings of this study, there are several substantial opportunities to further relieve energy pressure, improve the environment, and support socioeconomic activities, such as promotion of clean production and subsidies for technological improvements and changing the industrial structure. Additionally, adopting total environmental quantity constraints rather than intensity constraints is an urgent need in EIP planning. This study provides an applicable and feasible decision-making basis for the development of sustainable industrial parks. [ABSTRACT FROM AUTHOR]