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Abstract: Worker health and safety and environmental protection are not always considered simultaneously when attempting to reduce or eliminate hazardous materials from our environment. Cleaner Production-Pollution Prevention (CPPP), as primary prevention, has the ability to shift worker health and safety strategies from control to prevention, where exposure prevention precedes exposure control. This paper evaluates the effect of Cleaner Production-Pollution Prevention in the form of toxics use reduction (TUR) on worker health and safety at three printed wire board facilities covered under the Massachusetts Toxics Use Reduction Act. In-depth case study analysis, including an assessment of each facility’s health and safety status, explores the root causes of the worker health and safety changes attributable to the TUR interventions. By exploring the relationship between worker health and safety and environmental protection within the corporate structure; we can identify the factors driving companies to reduce toxics both inside and outside of their plants, as a single concern. While traditionally there have been divergent paths of practice for worker health and safety and environmental protection, the two are closely connected. It is important, however, to consider the implications of risk transfer/shifting between the general and work environment. In order to avoid this risk shifting, worker health and safety perspectives and goals must be more clearly incorporated into the Cleaner Production-Pollution Prevention/TUR management system. This study opens a dialog around the effects of environmental intervention programs on worker health and safety. We realize now that while CPPP/TUR reduces exposure to toxic substances in the general environment, it also offers unique opportunities to reaffirm primary prevention principles in the work environment. [Copyright &y& Elsevier]