To better understand the role of internal climate variability (ICV) in climate change impact studies, this study quantifies the importance of ICV [defined as the intermember variability of a single model initial-condition large ensemble (SMILE)] in relation to the anthropogenic climate change (ACC; defined as multimodel ensemble mean) in global and regional climate change using a criterion of time of emergence (ToE). The uncertainty of the estimated ToE is specifically investigated by using three SMILEs to estimate the ICV. The results show that using 1921--40 as a baseline period, the annual mean precipitation ACCis expected to emerge within this century over extratropical regions as well as along the equatorial band. However, ToEs are unlikely to occur, even by the end of this century, over intratropical regions outside of the equatorial band. In contrast, annual mean temperature ACC has already emerged from the temperature ICV for most of the globe. Similar spatial patterns are observed at the seasonal scale,while aweakerACCfor boreal summer (June--August) precipitation and additional ICV for boreal winter (December--February) temperature translate to later ToEs for some regions. In addition, the uncertainty of ToE related to the choice of a SMILEismostly less than 20 years for annualmean precipitation and temperature.However, it can be as large as 90 years for annualmean precipitation over someregions.Overall, results indicate that the choice of a SMILEis a significant source of uncertainty in the estimation of ToE and results based on only one SMILE should be interpreted with caution. [ABSTRACT FROM AUTHOR]