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Start Over Descriptor "hbv-aclf" Journal journal of clinical apheresis
2 results on '"hbv-aclf"'

1. A prognostic model for hepatitis B acute‐on‐chronic liver failure patients treated using a plasma exchange‐centered liver support system.

Author

Xie, Zhongyang, Violetta, Laurencia, Chen, Ermei, Huang, Kaizhou, Wu, Daxian, Xu, Xiaowei, Ouyang, Xiaoxi, Zhao, Yalei, and Li, Lanjuan

Subjects
HEPATITIS B, LIVER failure, CHRONIC hepatitis B, PROPORTIONAL hazards models, INTERNATIONAL normalized ratio, HEPATITIS B virus
Abstract

Aim: To determine the prognostic risk factors of patients with hepatitis B virus related acute‐on‐chronic liver failure (HBV‐ACLF) treated with plasma exchange (PE)‐based artificial liver support system (ALSS), and create a prognostic predictive model. Methods: A total of 304 HBV‐ACLF patients who received PE‐based ALSS were retrospectively analyzed. Potential prognostic factors on admission associated with survival were investigated. Of note, 101 additional patients were analyzed to validate the performance of the prognostic models. Results: According to 28‐day survival, a total of 207 patients who survived and 97 non‐survivors were identified in the derivation group. Overall, 268 (88.2%) ACLF cases were caused by reactivation of HBV. Cox proportional hazards regression model revealed that age, total bilirubin, ln (alpha‐fetoprotein [AFP]), encephalopathy (HE) score, sodium level, and international normalized ratio (INR) were independent risk factors of short‐term prognosis. We built a model named ALSS‐prognosis model (APM) to predict the 28‐day survival of HBV‐ACLF patients with ALSS; the model APM showed potentially better predictive performance for both the derivation and validation groups than MELD, MELD‐Na, and CLIF‐C ACLF score. Conclusions: Low AFP was found to be an independent risk factor for high mortality in HBV‐ACLF patients treated with PE‐based ALSS. We generated a new model containing AFP, namely APM, which showed potentially better prediction performance than MELD, MELD‐Na, and CLIF‐C ACLF score for short‐term outcomes, and could aid physicians in making optimal therapeutic decisions. [ABSTRACT FROM AUTHOR]

Published
2020
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2. A prognostic model for hepatitis B acute-on-chronic liver failure patients treated using a plasma exchange-centered liver support system

Author

Laurencia Violetta, Daxian Wu, Kaizhou Huang, Yalei Zhao, Xiaoxi Ouyang, Lanjuan Li, Zhongyang Xie, Xiaowei Xu, and Ermei Chen

Subjects
Adult, Male, medicine.medical_specialty, Bilirubin, Encephalopathy, AFP, HBV‐ACLF, 030204 cardiovascular system & hematology, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Acute on chronic liver failure, Derivation, Risk factor, Research Articles, Proportional Hazards Models, Retrospective Studies, Hepatitis B virus, Plasma Exchange, business.industry, ALSS, Acute-On-Chronic Liver Failure, Hematology, General Medicine, Hepatitis B, Middle Aged, medicine.disease, Prognosis, Hospitalization, Treatment Outcome, chemistry, Liver, ROC Curve, Area Under Curve, Support system, Female, business, 030215 immunology, Research Article
Abstract

Aim To determine the prognostic risk factors of patients with hepatitis B virus related acute‐on‐chronic liver failure (HBV‐ACLF) treated with plasma exchange (PE)‐based artificial liver support system (ALSS), and create a prognostic predictive model. Methods A total of 304 HBV‐ACLF patients who received PE‐based ALSS were retrospectively analyzed. Potential prognostic factors on admission associated with survival were investigated. Of note, 101 additional patients were analyzed to validate the performance of the prognostic models. Results According to 28‐day survival, a total of 207 patients who survived and 97 non‐survivors were identified in the derivation group. Overall, 268 (88.2%) ACLF cases were caused by reactivation of HBV. Cox proportional hazards regression model revealed that age, total bilirubin, ln (alpha‐fetoprotein [AFP]), encephalopathy (HE) score, sodium level, and international normalized ratio (INR) were independent risk factors of short‐term prognosis. We built a model named ALSS‐prognosis model (APM) to predict the 28‐day survival of HBV‐ACLF patients with ALSS; the model APM showed potentially better predictive performance for both the derivation and validation groups than MELD, MELD‐Na, and CLIF‐C ACLF score. Conclusions Low AFP was found to be an independent risk factor for high mortality in HBV‐ACLF patients treated with PE‐based ALSS. We generated a new model containing AFP, namely APM, which showed potentially better prediction performance than MELD, MELD‐Na, and CLIF‐C ACLF score for short‐term outcomes, and could aid physicians in making optimal therapeutic decisions.

Published
2018

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