Hepatitis B cirrhosis is a chronic progressive disease caused by hepatitis B virus ( HBV) infection and has various complications such as upper gastrointestinal bleeding, hepatic encephalopathy, and hepatorenal syndrome, and it may progress to liver cancer and even cause death in severe cases. In addition, HBV infection is also a high risk factor for renal injury, and patients with HBV infection had a higher incidence rate of renal injury than those without HBV infection. Renal injury does great harm to patients with hepatitis B cirrhosis, and some patients even have renal failure, with poor prognosis and high mortality. In recent years, hepatitis B cirrhosis with renal injury has become a research hotspot. This article briefly describes the research advances in the indices for hepatitis B cirrhosis with renal injury, compares the influence of different nucleotide analogues on renal function during antiviral therapy, and summarizes how to adjust the medication for patients with renal injury. It is pointed out that early identification and reasonable evaluation of renal function in patients has important clinical significance. [ABSTRACT FROM AUTHOR]