1. Pioglitazone Decreases Ambulatory Blood Pressure in Type 2 Diabetics With Difficult-to-Control Hypertension.
- Author
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Rivas, Beatriz de, Luque, Manuel, Martell, Nieves, Fernández, Cristina, and Fernández-Cruz, Arturo
- Abstract
Blood pressure (BP) control at recently established goals of <130/80 mm Hg is often difficult to achieve in diabetic patients. This work examines the effect of pioglitazone on 24-hour ambulatory BP monitoring in patients with type 2 diabetes and difficult-to-control hypertension. Twenty-seven participants with difficult-to-control hypertension (defined as ambulatory BP monitoring ≥125/75 mm Hg) taking antihypertensive medications (mean, 4.1±0.8 drugs) were enrolled in an open, prospective, blinded end point study of add-on therapy with pioglitazone 30 to 45 mg for 20 weeks. After 20 weeks of treatment, 24-hour ambulatory BP monitoring showed significant reductions (from 144±13 to 136±16 mm Hg systolic BP and from 79±9 to 76±10 mm Hg diastolic BP [P =.001]). Treatment was also associated with improvements in insulin sensitivity and glycemic and lipid profile. These findings suggest that pioglitazone could be a therapeutic option in diabetics who still have elevated BP values in spite of receiving treatment with at least 3 antihypertensive drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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