1. The Possible Roles of OPN-Regulated CEACAM1 Expression in Promoting the Survival of Activated T Cells and the Apoptosis of Oral Keratinocytes in Oral Lichen Planus Patients.
- Author
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Liu, Gui-Xiang, Xie, Qi, Zhou, Cheng-Jun, Zhang, Xiao-Ying, Ma, Bo-Long, Wang, Cheng-Qin, Wei, Feng-Cai, Qu, Xun, and Sun, Shan-Zhen
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T cells , *APOPTOSIS , *KERATINOCYTES , *CEA genes , *LICHEN planus , *ORAL mucosa , *CELL adhesion molecules , *OSTEOPONTIN , *AUTOIMMUNE diseases - Abstract
Oral lichen planus is a chronic inflammatory disorder of the oral mucosa that represents T cell-mediated autoimmune diseases. The regulation and roles of carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1), a novel immune molecule, in the immunopathogenesis of T cell-mediated autoimmune diseases remain unclear. In the current paper, CEACAM1 was found to be overexpressed in peripheral T cells and epithelial cells in oral lichen planus patients. A fraction of infiltrating inflammatory mononuclear cells in the lamina propria of the oral lichen planus mucosa also expressed CEACAM1. Importantly, for the first time, CEACAM1 expression in T cells and in normal human oral keratinocytes was demonstrated to be regulated differently by osteopontin in vitro. Furthermore, the apoptosis of oral keratinocytes and activated T cells can be markedly suppressed by CEACAM1-specific monoclonal antibodies. In conclusion, OPN-regulated CEACAM1 expression may play a critical role in the immunopathogenesis of oral lichen planus. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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