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Your search keyword '"Lodi, Lorenzo"' showing total 3 results
Start Over Author "Lodi, Lorenzo" Journal journal of clinical immunology
3 results on '"Lodi, Lorenzo"'

1. Progressive Depletion of B and T Lymphocytes in Patients with Ataxia Telangiectasia: Results of the Italian Primary Immunodeficiency Network

Author

Cirillo, Emilia, primary, Polizzi, Agata, additional, Soresina, Annarosa, additional, Prencipe, Rosaria, additional, Giardino, Giuliana, additional, Cancrini, Caterina, additional, Finocchi, Andrea, additional, Rivalta, Beatrice, additional, Dellepiane, Rosa M., additional, Baselli, Lucia A., additional, Montin, Davide, additional, Trizzino, Antonino, additional, Consolini, Rita, additional, Azzari, Chiara, additional, Ricci, Silvia, additional, Lodi, Lorenzo, additional, Quinti, Isabella, additional, Milito, Cinzia, additional, Leonardi, Lucia, additional, Duse, Marzia, additional, Carrabba, Maria, additional, Fabio, Giovanna, additional, Bertolini, Patrizia, additional, Coccia, Paola, additional, D’Alba, Irene, additional, Pession, Andrea, additional, Conti, Francesca, additional, Zecca, Marco, additional, Lunardi, Claudio, additional, Bianco, Manuela Lo, additional, Presti, Santiago, additional, Sciuto, Laura, additional, Micheli, Roberto, additional, Bruzzese, Dario, additional, Lougaris, Vassilios, additional, Badolato, Raffaele, additional, Plebani, Alessandro, additional, Chessa, Luciana, additional, and Pignata, Claudio, additional

Published
2022
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2. Immunological Evaluation of Patients Affected with Jacobsen Syndrome Reveals Profound Not Age-Related Lymphocyte Alterations

Author

Canessa Clementina, Raffaele Badolato, Stefano Rossi, Boaz Palterer, Francesco Saettini, Marco Chiarini, Daniele Moratto, Antonio Marzollo, Alessandro Plebani, Lodi Lorenzo, Manuela Baronio, Silvia Ricci, Alessandra Sottini, Luisa Gazzurelli, Luisa Imberti, Daniele Zama, Chiara Gorio, Linda Rossini, Vassilios Lougaris, Baronio M., Saettini F., Gazzurelli L., Rossi S., Marzollo A., Ricci S., Zama D., Palterer B., Clementina C., Lorenzo L., Chiarini M., Sottini A., Imberti L., Gorio C., Rossini L., Badolato R., Plebani A., Moratto D., and Lougaris V.

Subjects
medicine.medical_specialty, CD3, Lymphocyte, Immunology, T lymphocytes, Immunoglobulins, CD16, Gastroenterology, Flow cytometry, Jacobsen syndrome, Internal medicine, White blood cell, medicine, Immunoglobulin, Killer Cells, Immunology and Allergy, Humans, Jacobsen Distal 11q Deletion Syndrome, Lymphocyte Count, Child, Immunodeficiency, B-Lymphocytes, biology, medicine.diagnostic_test, B lymphocyte, business.industry, medicine.disease, Flow Cytometry, Killer Cells, Natural, medicine.anatomical_structure, Natural, biology.protein, B lymphocytes, Antibody, business
Abstract

Purpose Jacobsen syndrome (JS) is a rare form of genetic disorder that was recently classified as a syndromic immunodeficiency. Available detailed immunological data from JS patients are limited. Methods Clinical and immunological presentation of twelve pediatric patients with JS by means of revision of clinical records, flow cytometry, real-time PCR, and lymphocyte functional testing were collected. Results Recurrent infections were registered in 6/12 patients (50%), while bleeding episodes in 2/12 (16.7%). White blood cell and absolute lymphocyte counts were reduced in 8/12 (66.7%) and 7/12 (58.3%) patients, respectively. Absolute numbers of CD3+ and CD4+ T cells were reduced in 8/12 (66.7%) and 7/12 (58.3%), respectively. Of note, recent thymic emigrants (RTE) were reduced in all tested patients (9/9), with T-cell receptor excision circle analysis (TRECs) showing a similar trend in 8/9 patients; naive CD4+ T cells were low only in 5/11 patients (45.4%). Interestingly, B-cell counts, IgM memory B cells, and IgM serum levels were reduced in 10/12 (83.3%) patients. Natural killer (NK) cell counts were mostly normal but the percentages of CD16+CD56low/- cells were expanded in 7/7 patients tested. The observed immunological alterations did not correlate with patients' age. Finally, responses to proliferative stimuli were normal at presentation for all patients, although they may deteriorate over time. Conclusions Our data suggest that patients affected with JS may display important numeric and maturational alterations in the T-, B-, and NK-cell compartments. These findings suggest that JS patients should be regularly monitored from an immunological point of view.

Published
2021

3. Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies

Author

Lodi, Lorenzo, primary, Melki, Isabelle, additional, Bondet, Vincent, additional, Seabra, Luis, additional, Rice, Gillian I., additional, Carter, Edwin, additional, Lepelley, Alice, additional, Martin-Niclós, Maria José, additional, Al Adba, Buthaina, additional, Bader-Meunier, Brigitte, additional, Barth, Magalie, additional, Blauwblomme, Thomas, additional, Bodemer, Christine, additional, Boespflug-Tanguy, Odile, additional, Dale, Russel C., additional, Desguerre, Isabelle, additional, Ducrocq, Camille, additional, Dulieu, Fabienne, additional, Dumaine, Cécile, additional, Ellul, Pierre, additional, Hadchouel, Alice, additional, Hentgen, Véronique, additional, Hié, Miguel, additional, Hully, Marie, additional, Jeziorski, Eric, additional, Lévy, Romain, additional, Mochel, Fanny, additional, Orcesi, Simona, additional, Passemard, Sandrine, additional, Pouletty, Marie, additional, Quartier, Pierre, additional, Renaldo, Florence, additional, Seidl, Rainer, additional, Shetty, Jay, additional, Neven, Bénédicte, additional, Blanche, Stéphane, additional, Duffy, Darragh, additional, Crow, Yanick J., additional, and Frémond, Marie-Louise, additional

Published
2021
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