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Your search keyword '"Trizzino, Antonino"' showing total 7 results
Start Over Author "Trizzino, Antonino" Journal journal of clinical immunology
7 results on '"Trizzino, Antonino"'

1. Progressive Depletion of B and T Lymphocytes in Patients with Ataxia Telangiectasia: Results of the Italian Primary Immunodeficiency Network

Author

Cirillo, Emilia, primary, Polizzi, Agata, additional, Soresina, Annarosa, additional, Prencipe, Rosaria, additional, Giardino, Giuliana, additional, Cancrini, Caterina, additional, Finocchi, Andrea, additional, Rivalta, Beatrice, additional, Dellepiane, Rosa M., additional, Baselli, Lucia A., additional, Montin, Davide, additional, Trizzino, Antonino, additional, Consolini, Rita, additional, Azzari, Chiara, additional, Ricci, Silvia, additional, Lodi, Lorenzo, additional, Quinti, Isabella, additional, Milito, Cinzia, additional, Leonardi, Lucia, additional, Duse, Marzia, additional, Carrabba, Maria, additional, Fabio, Giovanna, additional, Bertolini, Patrizia, additional, Coccia, Paola, additional, D’Alba, Irene, additional, Pession, Andrea, additional, Conti, Francesca, additional, Zecca, Marco, additional, Lunardi, Claudio, additional, Bianco, Manuela Lo, additional, Presti, Santiago, additional, Sciuto, Laura, additional, Micheli, Roberto, additional, Bruzzese, Dario, additional, Lougaris, Vassilios, additional, Badolato, Raffaele, additional, Plebani, Alessandro, additional, Chessa, Luciana, additional, and Pignata, Claudio, additional

Published
2022
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3. The Italian Registry for Primary Immunodeficiencies (Italian Primary Immunodeficiency Network; IPINet): Twenty Years of Experience (1999–2019)

Author

Lougaris, Vassilios, primary, Pession, Andrea, additional, Baronio, Manuela, additional, Soresina, Annarosa, additional, Rondelli, Roberto, additional, Gazzurelli, Luisa, additional, Benvenuto, Alessio, additional, Martino, Silvana, additional, Gattorno, Marco, additional, Biondi, Andrea, additional, Zecca, Marco, additional, Marinoni, Maddalena, additional, Fabio, Giovanna, additional, Aiuti, Alessandro, additional, Marseglia, Gianluigi, additional, Putti, Maria Caterina, additional, Agostini, Carlo, additional, Lunardi, Claudio, additional, Tommasini, Alberto, additional, Bertolini, Patrizia, additional, Gambineri, Eleonora, additional, Consolini, Rita, additional, Matucci, Andrea, additional, Azzari, Chiara, additional, Danieli, Maria Giovanna, additional, Paganelli, Roberto, additional, Duse, Marzia, additional, Cancrini, Caterina, additional, Moschese, Viviana, additional, Chessa, Luciana, additional, Spadaro, Giuseppe, additional, Civino, Adele, additional, Vacca, Angelo, additional, Cardinale, Fabio, additional, Martire, Baldassare, additional, Carpino, Luigi, additional, Trizzino, Antonino, additional, Russo, Giovanna, additional, Cossu, Fausto, additional, Badolato, Raffaele, additional, Pietrogrande, Maria Cristina, additional, Quinti, Isabella, additional, Rossi, Paolo, additional, Ugazio, Alberto, additional, Pignata, Claudio, additional, and Plebani, Alessandro, additional

Published
2020
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4. Health-Related Quality of Life and Emotional Difficulties in Chronic Granulomatous Disease: Data on Adult and Pediatric Patients from Italian Network for Primary Immunodeficiency (IPINet)

Author

Pulvirenti, Federica, primary, Sangerardi, Maria, additional, Plebani, Alessandro, additional, Soresina, Annarosa, additional, Finocchi, Andrea, additional, Pignata, Claudio, additional, Cirillo, Emilia, additional, Trizzino, Antonino, additional, Aiuti, Alessandro, additional, Migliavacca, Maddalena, additional, Locatelli, Franco, additional, Bertaina, Alice, additional, Naviglio, Samuele, additional, Carrabba, Maria, additional, De Carli, Marco, additional, Barbaro, Maria Grazia Foschino, additional, Gattorno, Marco, additional, Quinti, Isabella, additional, and Martire, Baldassarre, additional

Published
2019
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5. Health-Related Quality of Life and Emotional Difficulties in Chronic Granulomatous Disease: Data on Adult and Pediatric Patients from Italian Network for Primary Immunodeficiency (IPINet).

Author

Pulvirenti, Federica, Sangerardi, Maria, Plebani, Alessandro, Soresina, Annarosa, Finocchi, Andrea, Pignata, Claudio, Cirillo, Emilia, Trizzino, Antonino, Aiuti, Alessandro, Migliavacca, Maddalena, Locatelli, Franco, Bertaina, Alice, Naviglio, Samuele, Carrabba, Maria, De Carli, Marco, Barbaro, Maria Grazia Foschino, Gattorno, Marco, Quinti, Isabella, and Martire, Baldassarre

Subjects
CHRONIC granulomatous disease, QUALITY of life, HEMATOPOIETIC stem cell transplantation, DISABILITIES, SOCIAL impact
Abstract

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by life-threatening infections, inflammation, and autoimmunity with an impact on health-related quality of life (HRQoL). Few data are available for children, whereas no study has been conducted in adults. Here, we investigated HRQoL and emotional functioning of 19 children and 28 adults enrolled in Italian registry for CGD. PEDsQL and SDQ were used for children and their caregivers, and adults completed the SF-12 questionnaire. Mean scores were compared with norms and with patients affected by chronic diseases. Comparisons were made for CGD patients who underwent or not hematopoietic stem cell transplantation (HSCT). When compared with norms, CGD children exhibited higher difficulties in social/school areas, peer relationship, and conduct/emotional problems (< 5 years of age), as scored by proxies. Differently, CGD adults reported higher difficulties both in mental and physical area than norms. Only for children, clinical status had a damaging effect on psychosocial and school dimensions, whereas age had a negative impact on social areas. No significant difference was observed between patients treated or not with HSCT. When compared with patients affected by chronic diseases, CGD children and adults both displayed fewer physical disabilities. Differently, in mental scale adults scored lower than those with rheumatology diseases and had similar impairment in comparison with patients with diabetes mellitus and cancer. This study emphasized the impact of CGD on HRQoL since infancy and its decline in adulthood, with emotional difficulties occurring early. HRQoL impairment should be considered in clinical picture of CGD and pro-actively assessed and managed by clinicians. [ABSTRACT FROM AUTHOR]

Published
2020
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6. Biweekly Hizentra® in Primary Immunodeficiency: a Multicenter, Observational Cohort Study (IBIS)

Author

Vultaggio, Alessandra, primary, Azzari, Chiara, additional, Ricci, Silvia, additional, Martire, Baldassarre, additional, Palladino, Valentina, additional, Gallo, Vera, additional, Pecoraro, Antonio, additional, Pignata, Claudio, additional, Spadaro, Giuseppe, additional, Graziani, Simona, additional, Moschese, Viviana, additional, Trizzino, Antonino, additional, Boggia, Giorgio Maria, additional, and Matucci, Andrea, additional

Published
2018
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7. Biweekly Hizentra® in Primary Immunodeficiency: a Multicenter, Observational Cohort Study (IBIS)

Author

Antonio Pecoraro, Antonino Trizzino, Silvia Ricci, Andrea Matucci, Baldassarre Martire, Claudio Pignata, Vera Gallo, Simona Graziani, Valentina Palladino, Viviana Moschese, Alessandra Vultaggio, Chiara Azzari, Giorgio Maria Boggia, Giuseppe Spadaro, Vultaggio, Alessandra, Azzari, Chiara, Ricci, Silvia, Martire, Baldassarre, Palladino, Valentina, Gallo, Vera, Pecoraro, Antonio, Pignata, Claudio, Spadaro, Giuseppe, Graziani, Simona, Moschese, Viviana, Trizzino, Antonino, Boggia, Giorgio Maria, and Matucci, Andrea

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pediatrics, medicine.drug_class, Immunology, Antibiotics, Infections, Observational period, Drug Administration Schedule, biweekly administration, Cohort Studies, Young Adult, 03 medical and health sciences, Medical microbiology, Humans, Immunology and Allergy, Medicine, In patient, Primary immunodeficiency disease, Settore MED/38 - Pediatria Generale e Specialistica, Ibis, biology, business.industry, Standard treatment, Immunologic Deficiency Syndromes, IBIS study, 20% subcutaneous immunoglobulin, biology.organism_classification, medicine.disease, Treatment Outcome, 030104 developmental biology, Patient Satisfaction, Immunoglobulin G, Primary immunodeficiency, Original Article, Female, business, Cohort study
Abstract

Immunoglobulin G (IgG) replacement therapy is a standard treatment for patients with primary immunodeficiency diseases (PIDs). Hizentra®, a 20% human subcutaneous IgG (SCIG), is approved for biweekly administration for PIDs. The aim of the multicenter IBIS study was to prospectively investigate the efficacy of biweekly Hizentra® compared with previous IVIG or SCIG treatment regimens in patients with PIDs. The study consisted of a 12-month retrospective period followed by 12-month prospective observational period. The main endpoints included pre-infusion IgG concentrations, proportion of patients with serious bacterial infections (SBIs), other infections, hospitalizations due to PID-related illnesses, and days with antibiotics during the study periods. Of the 36 patients enrolled in the study, 35 patients continued the study (mean age 26.1 ± 14.4 years; 68.6% male). The mean pre-infusion IgG levels for prior immunoglobulin regimens during the retrospective period (7.84 ± 2.09 g/L) and the prospective period (8.55 ± 1.76 g/L) did not show any significant variations (p = 0.4964). The mean annual rate of SBIs/patient was 0.063 ± 0.246 for both prospective and retrospective periods. No hospitalizations related to PIDs were reported during the prospective period versus one in the retrospective period. All patients were either very (76.5%) or quite (23.5%) satisfied with biweekly Hizentra® at the end of the study. In conclusion, the IBIS study provided real-world evidence on the efficacy of biweekly Hizentra® in patients with PIDs, thus verifying the data generated by the pharmacometric modeling and simulation study in a normal clinical setting.

Published
2018

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