1. JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice
- Author
-
Rivellini, Cristina, Porrello, Emanuela, Dina, Giorgia, Mrakic-Sposta, Simona, Vezzoli, Alessandra, Bacigaluppi, Marco, Gullotta, Giorgia Serena, Chaabane, Linda, Leocani, Letizia, Marenna, Silvia, Colombo, Emanuela, Farina, Cinthia, Newcombe, Jia, Nave, Klaus-Armin, Pardi, Ruggero, Quattrini, Angelo, and Previtali, Stefano C.
- Subjects
Binding proteins -- Physiological aspects -- Health aspects ,Oligodendroglia -- Genetic aspects -- Health aspects ,Demyelinating diseases -- Development and progression -- Genetic aspects ,Health care industry - Abstract
Oligodendrocytes are the primary target of demyelinating disorders, and progressive neurodegenerative changes may evolve in the CNS. DNA damage and oxidative stress are considered key pathogenic events, but the underlying molecular mechanisms remain unclear. Moreover, animal models do not fully recapitulate human diseases, complicating the path to effective treatments. Here we report that mice with cell-autonomous deletion of the nuclear COP9 signalosome component CSN5 (JAB1) in oligodendrocytes develop DNA damage and defective DNA repair in myelinating glial cells. Interestingly, oligodendrocytes lacking JAB1 expression underwent a senescence-like phenotype that fostered chronic inflammation and oxidative stress. These mutants developed progressive CNS demyelination, microglia inflammation, and neurodegeneration, with severe motor deficits and premature death. Notably, blocking microglia inflammation did not prevent neurodegeneration, whereas the deletion of [p21.sup.CIP1] but not [p.sup.6 INK4a] pathway ameliorated the disease. We suggest that senescence is key to sustaining neurodegeneration in demyelinating disorders and may be considered a potential therapeutic target., Introduction Myelin is a highly specialized protein- and lipid-rich membrane that wraps around axons in the central and peripheral nervous systems (CNS and PNS). It is made by oligodendrocytes in [...]
- Published
- 2022
- Full Text
- View/download PDF