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Start Over Author "Del Prete G" Journal journal of clinical investigation
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6. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses.

Author

Amedei A, Cappon A, Codolo G, Cabrelle A, Polenghi A, Benagiano M, Tasca E, Azzurri A, D'Elios MM, Del Prete G, and de Bernard M

Subjects
Adult, Allergens metabolism, Allergens pharmacology, Bacterial Proteins pharmacology, CD4 Antigens metabolism, Cells, Cultured, Dendritic Cells metabolism, Female, Genes, MHC Class II, Granulocytes metabolism, Humans, Immunity, Innate, Interferon-gamma metabolism, Interleukin-12 biosynthesis, Interleukin-23, Interleukin-23 Subunit p19, Interleukins biosynthesis, Male, Middle Aged, Monocytes metabolism, Neutrophils metabolism, Phenotype, Th1 Cells metabolism, Time Factors, Toll-Like Receptor 2 agonists, Toll-Like Receptor 2 metabolism, Tumor Necrosis Factor-alpha metabolism, Up-Regulation, Bacterial Proteins metabolism, Helicobacter pylori metabolism, Th1 Cells immunology
Abstract

The Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor of H. pylori that stimulates in neutrophils high production of oxygen radicals and adhesion to endothelial cells. We report here that HP-NAP is a TLR2 agonist able to induce the expression of IL-12 and IL-23 by neutrophils and monocytes. Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines resulted in a remarkable increase in the number of IFN-gamma-producing T cells and decrease of IL-4-secreting cells, thus shifting the cytokine profile of antigen-activated human T cells from Th2 to a Th1 cytotoxic phenotype. We also found that in vivo HP-NAP elicited an antigen-specific Th1-polarized T cell response in the gastric mucosa of H. pylori-infected patients. These data indicate HP-NAP as an important factor of H. pylori able to elicit cells of the innate immune system to produce IL-12 and IL-23, and they suggest it as a new tool for promoting Th1 immune responses.

Published
2006
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