1. A nonclassical vitamin D receptor pathway suppresses renal fibrosis
- Author
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Ito, Ichiaki, Waku, Tsuyoshi, Aoki, Masato, Abe, Rumi, Nagai, Yu, Watanabe, Tatsuya, Nakajima, Yuka, Ohkido, Ichiro, Yokoyama, Keitaro, Miyachi, Hiroyuki, Shimizu, Toshiyuki, Murayama, Akiko, Kishimoto, Hiroyuki, Nagasawa, Kazuo, and Yanagisawa, Junn
- Subjects
Fibrosis -- Genetic aspects -- Care and treatment -- Research ,Alfacalcidol -- Usage -- Health aspects ,Calcifediol -- Usage -- Health aspects ,Vitamin D -- Usage -- Health aspects ,Transforming growth factors -- Physiological aspects -- Genetic aspects -- Research ,Health care industry - Abstract
The TGF-β--superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-β--signal transduction is known to be involved in tissue fibrosis, including renal fibrosis. Here, we found that 1,25-dihydroxyvitamin [D.sub.3]--bound [...]
- Published
- 2013