1. Polymorphisms of human leukocyte antigen B*27 on clinical phenotype of spondyloarthritis in Chinese
- Author
-
Minghao Guo, Qing-Feng Yin, Hai-Jun Ma, Tie-Chui Zhu, Yun Liu, and Yin Wu
- Subjects
Adult ,Male ,Microbiology (medical) ,China ,Adolescent ,Clinical Biochemistry ,Biology ,Polymerase Chain Reaction ,law.invention ,Pathogenesis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,law ,medicine ,Humans ,Immunology and Allergy ,Family history ,Young adult ,Allele ,Genotyping ,HLA-B27 Antigen ,Research Articles ,Polymerase chain reaction ,030203 arthritis & rheumatology ,Polymorphism, Genetic ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Sacroiliitis ,Hematology ,medicine.disease ,Subtyping ,Medical Laboratory Technology ,Cross-Sectional Studies ,Phenotype ,Immunology ,Spondylarthropathies ,Female ,030215 immunology - Abstract
Background In recent years, an ever-increasing number of alleles of human leukocyte antigen B*27 (HLA-B*27) have been identified. This study aimed to establish an updated method for HLA-B*27 subtyping, and to investigate the impact of HLA-B*27 polymorphisms on the clinical phenotype of spondyloarthritis (SpA). Methods Overall, 184 SpA patients were recruited for analyzing diversity of HLA-B*27 via an updated high-resolution polymerase chain reaction amplification with sequence specific primers (PCR-SSP). Results The prevalence of HLA-B*27 was 94.0%, and four subtypes were identified including HLA-B*2704 (77.5%), B*2705 (20.2%), B*2707 (1.7%), and B*2724 (0.6%). There was an obvious male predominance (P=.05) and markedly elevated C-reaction protein (CRP) in B*27 positive SpA (P
- Published
- 2017