1. Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer.
- Author
-
Jackson, Jamaal C., Sanchez, Darren, Johns, Andrew C., Campbell, Matthew T., Aydin, Ahmet M., Gokden, Neriman, Maraboyina, Sanjay, Muesse, Jason L., Ward, John F., Pisters, Louis L., Zacharias, Niki M., Guo, Charles C., and Tu, Shi-Ming
- Subjects
GERM cell tumors ,TESTIS tumors ,TROPHOBLASTIC tumors ,TREATMENT effectiveness ,TERATOMA ,SURGICAL excision - Abstract
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF