1. Role of Lipid-Lowering Therapy in Peripheral Artery Disease.
- Author
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Belur, Agastya D., Shah, Aangi J., Virani, Salim S., Vorla, Mounica, and Kalra, Dinesh K.
- Subjects
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PERIPHERAL vascular diseases , *LOW density lipoproteins , *SYMPTOMS , *ARTERIAL stenosis , *THROMBOSIS - Abstract
Atherosclerosis is a multifactorial, lipoprotein-driven condition that leads to plaque formation within the arterial tree, leading to subsequent arterial stenosis and thrombosis that accounts for a large burden of cardiovascular morbidity and mortality globally. Atherosclerosis of the lower extremities is called peripheral artery disease and is a major cause of loss in mobility, amputation, and critical limb ischemia. Peripheral artery disease is a common condition with a gamut of clinical manifestations that affects an estimated 10 million people in the United States of America and 200 million people worldwide. The role of apolipoprotein B-containing lipoproteins, such as LDL and remnant lipoproteins in the development and progression of atherosclerosis, is well-established. The focus of this paper is to review existing data on lipid-lowering therapies in lower extremity atherosclerotic peripheral artery disease. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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