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This document is an editorial from the Journal of Clinical Medicine that discusses the paradigm shift towards personalized interventions in the fields of psychology and health. The editorial highlights several studies included in a special issue of the journal that focus on individualized treatment strategies to improve therapeutic outcomes for diverse populations. The studies cover a range of topics, including culturally sensitive behavioral interventions, gender variations in treatment responses, the role of family support in mitigating the effects of social anxiety, psychological states of obese teenagers, the impact of the COVID-19 pandemic on individuals with dysregulated eating habits, sleep disturbances and socioeconomic status, health-related quality of life after pediatric traumatic brain injury, and the association between generalized anxiety disorder and smartphone dependence in Korean teenagers. The editorial concludes by emphasizing the importance of personalized approaches in optimizing mental and physical well-being and calls for further research and innovation in this field. [Extracted from the article]