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7 results on '"Constantinescu, Catalin"'

4. B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?

Author

Desmirean, Minodora, primary, Rauch, Sebastian, additional, Jurj, Ancuta, additional, Pasca, Sergiu, additional, Iluta, Sabina, additional, Teodorescu, Patric, additional, Berce, Cristian, additional, Zimta, Alina-Andreea, additional, Turcas, Cristina, additional, Tigu, Adrian-Bogdan, additional, Moldovan, Cristian, additional, Paris, Irene, additional, Steinheber, Jakob, additional, Richlitzki, Cedric, additional, Constantinescu, Catalin, additional, Sigurjonsson, Olafur Eysteinn, additional, Dima, Delia, additional, Petrushev, Bobe, additional, and Tomuleasa, Ciprian, additional

Published
2020
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5. Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies

Author

Constantinescu, Catalin, primary, Pasca, Sergiu, additional, Zimta, Alina-Andreea, additional, Tat, Tiberiu, additional, Rus, Ioana, additional, Teodorescu, Patric, additional, Iluta, Sabina, additional, Tanase, Alina, additional, Colita, Anca, additional, Sigurjonsson, Olafur, additional, Einsele, Hermann, additional, and Tomuleasa, Ciprian, additional

Published
2020
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6. Approach to the Adult Acute Lymphoblastic Leukemia Patient

Author

Sas, Valentina, Moisoiu, Vlad, Teodorescu, Patric, Tranca, Sebastian, Pop, Laura, Iluta, Sabina, Pasca, Sergiu, Blag, Cristina, Man, Sorin, Roman, Andrei, Constantinescu, Catalin, Rus, Ioana, Buse, Mihail, Fetica, Bogdan, Marian, Mirela, Selicean, Cristina, Berindan-Neagoe, Ioana, Petrushev, Bobe, Bumbea, Horia, Tanase, Alina, Zdrenghea, Mihnea, Fuji, Shigeo, Kitano, Shigehisa, Tomuleasa, Ciprian, and Transplantation, Romanian-Japanese Working Group of the Romanian Society for Bone Marrow

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, medicine.medical_treatment, lcsh:Medicine, Hematopoietic stem cell transplantation, acute lymphoblastic leukemia, Article, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, Risk groups, Internal medicine, White blood cell, hemic and lymphatic diseases, medicine, clinical management, follow-up, Chemotherapy, Hematology, medicine.diagnostic_test, business.industry, lcsh:R, General Medicine, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Adult Acute Lymphoblastic Leukemia, business, Tyrosine kinase
Abstract

During recent decades, understanding of the molecular mechanisms of acute lymphoblastic leukemia (ALL) has improved considerably, resulting in better risk stratification of patients and increased survival rates. Age, white blood cell count (WBC), and specific genetic abnormalities are the most important factors that define risk groups for ALL. State-of-the-art diagnosis of ALL requires cytological and cytogenetical analyses, as well as flow cytometry and high-throughput sequencing assays. An important aspect in the diagnostic characterization of patients with ALL is the identification of the Philadelphia (Ph) chromosome, which warrants the addition of tyrosine kinase inhibitors (TKI) to the chemotherapy backbone. Data that support the benefit of hematopoietic stem cell transplantation (HSCT) in high risk patient subsets or in late relapse patients are still questioned and have yet to be determined conclusive. This article presents the newly published data in ALL workup and treatment, putting it into perspective for the attending physician in hematology and oncology.

Published
2019
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7. Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician.

Author

Constantinescu, Catalin, Bodolea, Constantin, Pasca, Sergiu, Teodorescu, Patric, Dima, Delia, Rus, Ioana, Tat, Tiberiu, Achimas-Cadariu, Patriciu, Tanase, Alina, Tomuleasa, Ciprian, and Einsele, Hermann

Subjects
*STEM cell transplantation, *HEMATOLOGISTS, *PEDIATRIC hematology, *PHYSICIANS, *INTENSIVE care units, *DISSOLVED oxygen in water, *C-reactive protein
Abstract

The initial management of the hematology patient in a critical state is crucial and poses a great challenge both for the hematologist and the intensive care unit (ICU) physician. After years of clinical practice, there is still a delay in the proper recognition and treatment of critical situations, which leads to late admission to the ICU. There is a much-needed systematic ABC (Airway, Breathing, Circulation) approach for the patients being treated on the wards as well as in the high dependency units because the underlying hematological disorder, as well as disease-related complications, have an increasing frequency. Focusing on score-based decision-making on the wards (Modified Early Warning Score (MEWS), together with Quick Sofa score), active sepsis screening with inflammation markers (C-reactive protein, procalcitonin, and presepsin), and assessment of microcirculation, organ perfusion, and oxygen supply by using paraclinical parameters from the ICU setting (lactate, central venous oxygen saturation (ScVO2), and venous-to-arterial carbon dioxide difference), hematologists can manage the immediate critical patient and improve the overall outcome. [ABSTRACT FROM AUTHOR]

Published
2019
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