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14 results on '"Koch, Alexander"'

2. Association of Alpha-1 Antitrypsin Pi*Z Allele Frequency and Progressive Liver Fibrosis in Two Chronic Hepatitis C Cohorts

Author

Mücke, Victoria Therese, primary, Fischer, Janett, additional, Mücke, Marcus Maximilian, additional, Teumer, Alexander, additional, Koch, Alexander, additional, Vermehren, Johannes, additional, Fromme, Malin, additional, Zeuzem, Stefan, additional, Trautwein, Christian, additional, Sarrazin, Christoph, additional, Berg, Thomas, additional, Zhou, Biaohuan, additional, and Hamesch, Karim, additional

Published
2022
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4. Association of Alpha-1 Antitrypsin Pi*Z Allele Frequency and Progressive Liver Fibrosis in Two Chronic Hepatitis C Cohorts.

Author

Mücke, Victoria Therese, Fischer, Janett, Mücke, Marcus Maximilian, Teumer, Alexander, Koch, Alexander, Vermehren, Johannes, Fromme, Malin, Zeuzem, Stefan, Trautwein, Christian, Sarrazin, Christoph, Berg, Thomas, Zhou, Biaohuan, and Hamesch, Karim

Subjects
HEPATIC fibrosis, CHRONIC hepatitis C, GENE frequency, TRYPSIN inhibitors, ALPHA 1-antitrypsin deficiency, DISEASE risk factors
Abstract

(1) Background: The inherited alpha-1 antitrypsin (A1AT) deficiency variant 'Pi*Z' emerged as a genetic modifier of chronic liver disease. Controversial data exist on the relevance of heterozygous Pi*Z carriage ('Pi*MZ' genotype) as an additional risk factor in patients with chronic viral hepatitis C to develop progressive liver fibrosis. (2) Methods: Two prospectively recruited cohorts totaling 572 patients with therapy-naïve chronic viral hepatitis C (HCV) were analyzed. The Frankfurt cohort included 337 patients and a second cohort from Leipzig included 235 patients. The stage of liver fibrosis was assessed by liver biopsy, AST-to-platelet ratio index (APRI) score and Fibrosis-4 (FIB-4) score (Frankfurt) as well as liver stiffness measurement (LSM) via transient elastography (Leipzig). All patients were genotyped for the Pi*Z variant (rs28929474) of the SERPINA1 gene. (3) Results: In the Frankfurt cohort, 16/337 (4.7%) patients carried the heterozygous Pi*Z allele while 10/235 (4.3%) in the Leipzig cohort were Pi*Z carriers. In both cohorts, there was no higher proportion of Pi*Z heterozygosity in patients with cirrhosis compared to patients without cirrhosis or patients with cirrhosis vs. no liver fibrosis. Accordingly, Pi*Z frequency was not different in histological or serological stages of liver fibrosis (F0–F4) and showed no clear association with LSM. (4) Conclusions: Evaluation in two representative HCV cohorts does not indicate Pi*Z heterozygosity as a clinically relevant disease modifier in chronic HCV infection. However, validation in even larger cohorts with longitudinal follow-up is warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Decreased Bone Mineral Density Is a Predictor of Poor Survival in Critically Ill Patients

Author

Schulze-Hagen, Maximilian F., primary, Roderburg, Christoph, additional, Wirtz, Theresa H., additional, Jördens, Markus S., additional, Bündgens, Lukas, additional, Abu Jhaisha, Samira, additional, Hohlstein, Philipp, additional, Brozat, Jonathan F., additional, Bruners, Philipp, additional, Loberg, Christina, additional, Kuhl, Christiane, additional, Trautwein, Christian, additional, Tacke, Frank, additional, Luedde, Tom, additional, Loosen, Sven H., additional, and Koch, Alexander, additional

Published
2021
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7. Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study

Author

Mechelinck, Mare, primary, Hartmann, Bianca, additional, Hamada, Sandra, additional, Becker, Michael, additional, Andert, Anne, additional, Ulmer, Tom Florian, additional, Neumann, Ulf Peter, additional, Wirtz, Theresa Hildegard, additional, Koch, Alexander, additional, Trautwein, Christian, additional, Roehl, Anna Bettina, additional, Rossaint, Rolf, additional, and Hein, Marc, additional

Published
2020
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8. A Combined Score of Circulating miRNAs Allows Outcome Prediction in Critically Ill Patients

Author

Roderburg, Christoph, Benz, Fabian, Koch, Alexander, Loosen, Sven, Spehlmann, Martina, Luedde, Mark, Wree, Alexander, Vucur, Mihael, Trautwein, Christian, Tacke, Frank, and Lüdde, Tom

Subjects
sepsis, lcsh:R, lcsh:Medicine, biomarker, critical illness, ddc:610, prognosis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Article, miRNA
Abstract

Journal of Clinical Medicine 8(10), 1644 (2019). doi:10.3390/jcm8101644, Published by MDPI, Basel

Published
2019
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9. Differential Gene Expression in Circulating CD14+ Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis

Author

Liepelt, Anke, primary, Hohlstein, Philipp, additional, Gussen, Hendrik, additional, Xue, Jia, additional, Aschenbrenner, Anna C., additional, Ulas, Thomas, additional, Buendgens, Lukas, additional, Warzecha, Klaudia T., additional, Bartneck, Matthias, additional, Luedde, Tom, additional, Trautwein, Christian, additional, Schultze, Joachim L., additional, Koch, Alexander, additional, and Tacke, Frank, additional

Published
2020
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14. Differential Gene Expression in Circulating CD14 + Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis.

Author

Liepelt A, Hohlstein P, Gussen H, Xue J, Aschenbrenner AC, Ulas T, Buendgens L, Warzecha KT, Bartneck M, Luedde T, Trautwein C, Schultze JL, Koch A, and Tacke F

Abstract

Critical illness and sepsis are characterized by drastic changes in the systemic innate immune response, particularly involving monocytes. The exact monocyte activation profile during sepsis, however, has remained obscure. Therefore, we prospectively analyzed the gene expression profile of circulating CD14 + monocytes from healthy volunteers ( n = 54) and intensive care unit (ICU) patients ( n = 76), of which n = 36 had sepsis. RNA sequencing of selected samples revealed that monocytes from septic ICU patients display a peculiar activation pattern, which resembles characteristic functional stages of monocyte-derived macrophages and is distinct from controls or non-sepsis ICU patients. Focusing on 55 highly variable genes selected for further investigation, arachidonate 5-lipoxygenase-activating protein (ALOX5AP) was highly upregulated in monocytes of ICU patients and only normalized during 7 days in the ICU in non-sepsis patients. Strikingly, low monocytic guanine nucleotide exchange factor 10-like protein (ARHGEF10L) mRNA expression was associated with the disease severity and mortality of ICU patients. Collectively, our comprehensive analysis of circulating monocytes in critically ill patients revealed a distinct activation pattern, particularly in ICU patients with sepsis. The association with disease severity, the longitudinal recovery or lack thereof during the ICU stay, and the association with prognosis indicate the clinical relevance of monocytic gene expression profiles during sepsis., Competing Interests: The authors declare no conflicts of interest related to this work.

Published
2020
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