8 results on '"Kraneveld, Aletta D."'
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2. Pandemic Preparedness: Maintaining Adequate Immune Fitness by Attaining a Normal, Healthy Body Weight
- Author
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Kiani, Pantea, primary, Mulder, Kiki E. W., additional, Balikji, Jessica, additional, Kraneveld, Aletta D., additional, Garssen, Johan, additional, and Verster, Joris C., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Pandemic Preparedness: The Importance of Adequate Immune Fitness
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Kiani, Pantea, primary, Balikji, Jessica, additional, Kraneveld, Aletta D., additional, Garssen, Johan, additional, Bruce, Gillian, additional, and Verster, Joris C., additional
- Published
- 2022
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4. The Assessment of Immune Fitness.
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Verster, Joris C., Kraneveld, Aletta D., and Garssen, Johan
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IMMUNITY , *BODY fluids , *IMMUNE system , *BIOMARKERS - Abstract
Immune fitness (i.e., adequate functioning of the immune system) is essential to maintain health, prevent and resolve disease, and improve quality of life. This article provides an overview of how to assess immune fitness. It discusses how a single-item rating scale can be used to assess immune fitness. The scale can be used in conjunction with a single "yes" or "no" question asking whether the individual is experiencing reduced immune fitness. Retrospective assessments can be complemented with the Immune Status Questionnaire (ISQ) to provide more insight into the type and frequency of experiencing specific immune-related complaints. Momentary assessments of immune fitness can be complemented with biomarker measurements in body fluids. As individuals may be unaware of systemic inflammation (e.g., biomarker concentrations outside the normal range), it remains critical to combine immune fitness assessments with biomarker measurements of immune functioning. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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5. The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover
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van de Loo, Aurora J A E, Mackus, Marlou, Kwon, Oran, Krishnakumar, Illathu Madhavamenon, Garssen, Johan, Kraneveld, Aletta D, Scholey, Andrew, Verster, Joris C, Afd Pharmacology, IRAS OH Toxicology, dIRAS RA-1, Pharmacology, Afd Pharmacology, IRAS OH Toxicology, dIRAS RA-1, and Pharmacology
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malondialdehyde ,medicine.medical_specialty ,8-isoprostane ,lcsh:Medicine ,Hangovers ,Alcohol ,macromolecular substances ,medicine.disease_cause ,Article ,C-reactive protein ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,0502 economics and business ,medicine ,oxidative stress ,Ethanol metabolism ,Ethanol ,biology ,business.industry ,alcohol ,lcsh:R ,05 social sciences ,Acetaldehyde ,General Medicine ,medicine.disease ,Malondialdehyde ,cytokines ,Endocrinology ,chemistry ,hangover ,biology.protein ,050211 marketing ,ethanol ,acetate ,business ,030217 neurology & neurosurgery ,Oxidative stress ,acetaldehyde - Abstract
An increasing number of studies are focusing on the inflammatory response to alcohol as a potentially important determinant of hangover severity. In this article, data from two studies were re-evaluated to investigate the relationship between hangover severity and relevant biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol. Hangover severity was significantly and positively correlated with blood concentrations of biomarkers of the inflammatory response to alcohol, in particular, Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-&alpha, ) and C-reactive protein (CRP). At 4 h after alcohol consumption, blood ethanol concentration (but not acetaldehyde) was significantly and positively associated with elevated levels of IL-6, suggesting a direct inflammatory effect of ethanol. In addition, biomarkers of oxidative stress, i.e., malondialdehyde and 8-isoprostrane, were significantly correlated with hangover severity, suggesting that oxidative stress also contributes to the inflammatory response. The timing of the assessments suggests initial slow elimination of ethanol in the first hours after alcohol consumption. As a consequence, more ethanol is present in the second half of the night and the next morning, which will elicit more oxidative stress and a more profound inflammatory response. Together, these processes result in more severe hangovers.
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- 2020
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6. The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover
- Author
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Mackus, Marlou, primary, Loo, Aurora JAE van de, additional, Garssen, Johan, additional, Kraneveld, Aletta D., additional, Scholey, Andrew, additional, and Verster, Joris C., additional
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- 2020
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7. Dietary Nutrient Intake, Alcohol Metabolism, and Hangover Severity
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Verster, Joris C., Vermeulen, Sterre A., van de Loo, Aurora J. A. E., Balikji, Stephanie, Kraneveld, Aletta D., Garssen, Johan, Scholey, Andrew, Afd Pharmacology, One Health Toxicologie, dIRAS RA-1, Pharmacology, Afd Pharmacology, One Health Toxicologie, dIRAS RA-1, and Pharmacology
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caloric intake ,maximum likelihood method ,vomiting ,food frequency questionnaire ,urinalysis ,lcsh:Medicine ,Physiology ,Hangovers ,Alcohol ,vitamin D ,Urine ,somnolence ,chemistry.chemical_compound ,0302 clinical medicine ,Nutrient ,sensitivity analysis ,social drinker ,alcohol blood level ,030212 general & internal medicine ,media_common ,clinical article ,barbituric acid derivative ,alcohol ,zinc ,alcohol dehydrogenase ,article ,General Medicine ,cannabinoid ,fluid intake ,opiate ,Nicotinic acid ,appetite ,female ,nutritional assessment ,hangover ,diet supplementation ,depression ,bootstrapping ,behavior assessment ,disease severity ,benzodiazepine ,alcoholic beverage ,headache ,stomach pain ,energy conversion ,media_common.quotation_subject ,alcohol consumption ,amphetamine ,cocaine ,psychosocial environment ,shivering ,03 medical and health sciences ,body weight ,male ,nutrients ,medicine ,Vitamin D and neurology ,controlled study ,human ,Ethanol metabolism ,nicotinic acid ,nicotinamide adenine dinucleotide ,dizziness ,business.industry ,lcsh:R ,Acetaldehyde ,alcohol oxidation ,Appetite ,Nutrients ,medicine.disease ,chemistry ,aldehyde dehydrogenase isoenzyme 2 ,alcohol metabolism ,lifestyle modification ,business ,dietary intake ,030217 neurology & neurosurgery ,acetaldehyde - Abstract
Several dietary components have been shown to influence alcohol metabolism and thereby potentially affect the development of a hangover. From the literature, it is evident that dietary nicotinic acid and zinc play a pivotal role in the oxidation of ethanol into acetaldehyde. The aim of the current study was to associate dietary intake of nicotinic acid and zinc with hangover severity. To this end, data from n = 23 healthy social drinkers who participated in a naturalistic hangover study were analyzed. n = 10 of them reported to be hangover-resistant (the control group), whereas n = 13 reported to have regular hangovers (the hangover-sensitive group). Two 24 h dietary recall records were completed, one for the day of alcohol consumption and another one for an alcohol-free control day. Dietary nutrient intake was averaged and did not significantly differ between hangover-sensitive and hangover-resistant drinkers. For the hangover-sensitive drinkers, partial correlations with overall hangover severity were computed, controlling for estimated blood alcohol concentration. A bootstrapping technique was applied to account for the relatively small sample size. The results showed that dietary intake of nicotinic acid (rPB = &minus, 0.521) and zinc (rPB = &minus, 0.341) were significantly and negatively associated (p <, 0.002) with overall hangover severity. Dietary zinc intake was also significantly and negatively associated with severity of vomiting (rPB = &minus, 0.577, p <, 0.002). No significant associations with hangover severity were found for other nutrients, such as fat and fibers. In conclusion, this study suggests that social drinkers who have a higher dietary intake of nicotinic acid and zinc report significantly less severe hangovers. As hangover-resistant and hangover-sensitive drinkers had a similar dietary nutrient intake, the claim of being hangover-resistant must be based on other unknown biopsychosocial factors. These findings should be replicated in a larger sample and include more elaborate food frequency questionnaires or nutrient-specific dietary intake records for zinc and nicotinic acid, and preferably accompanied by nutrient assessments in urine and/or blood.
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- 2019
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8. The Association of Insomnia, Perceived Immune Functioning, and Irritable Bowel Syndrome Complaints.
- Author
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Balikji, Stephanie, Mackus, Marlou, Brookhuis, Karel A., Garssen, Johan, Kraneveld, Aletta D., Roth, Thomas, and Verster, Joris C.
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INSOMNIACS ,IRRITABLE colon ,QUALITY of life ,HEALTH status indicators ,SLEEP disorders ,PATIENTS - Abstract
Background: Irritable bowel syndrome (IBS) can have a significant negative impact on quality of life, mood and wellbeing. The aim of this study was to investigate the association between experiencing IBS symptoms and insomnia, and perceived health status. Method: An online survey was conducted among
n = 1950 Dutch university students (83.6% women). IBS was assessed with the Birmingham IBS Symptom Questionnaire, quality of life with the WHO-5 wellbeing index, and sleep outcomes with the SLEEP-50 questionnaire. Perceived immune functioning and general health were assessed using 1-item scales. Results: IBS symptom severity was significantly associated with insomnia complaints (r = 0.32,p = 0.0001), sleep quality (r = −0.21,p = 0.0001), sleep onset latency (r = 0.11,p = 0.0001) and the number of nightly awakenings (r = 0.24,p = 0.0001). Total sleep time was not significantly associated with IBS symptom severity. Significant correlations were also found between IBS symptom severity and perceived general health (r = −0.30,p = 0.0001), perceived immune functioning (r= −0.25,p = 0.0001), and quality of life (r = −0.24,p = 0.0001). Conclusions: Experiencing IBS complaints is associated with reduced perceived immune functioning, a poorer perception of general health, and sleep disturbances. These effects are reflected in a significantly lower reported quality of life in subjects with more IBS and/or sleep complaints. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
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