1. Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination
- Author
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Francisco Gómez Preciado, Rosa Alejandra De Carvalho Ovalles, Sergi Codina, Laura Donadeu, Alexandre Favà, Laura Martinez Valenzuela, Diego Sandoval, Bárbara Fernández-Cidón, Oriol Bestard, Pedro Alia-Ramos, Montserrat Gomà, Edoardo Melilli, and Josep M Cruzado
- Subjects
SARS-CoV-2 ,vaccine ,COVID-19 ,collapsing ,glomerulonephritis ,mRNA ,Medicine - Abstract
With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.
- Published
- 2022
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