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Your search keyword '"Valentina Agnese"' showing total 4 results
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4 results on '"Valentina Agnese"'

1. Psychological Well-Being of Children with Asthma and Their Parents.

Author

Ferraro, Valentina Agnese, Spaggiari, Silvia, Zanconato, Stefania, Traversaro, Letizia, Carraro, Silvia, and Di Riso, Daniela

Subjects
*PSYCHOLOGICAL well-being, *ASTHMA in children, *PSYCHOLOGICAL adaptation, *PARENTAL influences, *MOTHERS, *SEPARATION anxiety
Abstract

Background/Objectives: The literature reports that emotional disorders in asthmatic children and their parents may affect asthma control. This research explores the baseline psychological well-being of asthmatic children and their mothers' and fathers' psychological functioning, focusing on the influence of the parents' anxiety and separation anxiety on children's asthma. Methods: In this cross-sectional study, we enrolled children with non-severe asthma and their parents, and a group of healthy children and their parents. The asthmatic children underwent anamnestic investigation, including asthma control and spirometry. Then, both the asthmatic and control triads filled a survey assessing their psychological functioning. Results: Among the 40 asthmatic children enrolled (8–18 years old), most had good clinical control maintained with GINA (Global Initiative for Asthma) therapy step 1–2 (14 patients, 35%) or step 3–4 (26 patients, 65%); 12 patients (30%) had at least one steroid course in the year before enrollment. They exhibited normal psychological adjustment but elevated levels of general (U = 179,500; p < 0.001) and state anxiety (U = 170,000; p < 0.001) compared to healthy peers. Additionally, the asthmatic children's mothers displayed higher levels of separation anxiety compared to the fathers (t = −2.865, p = 0.006). Increased separation anxiety in the mothers corresponded to a history of at least one exacerbation in the previous year. Conclusions: The asthmatic children exhibited normal psychological adjustment with higher general and state anxiety. Also, their mothers showed greater levels of separation anxiety compared to their fathers. Lastly, higher mothers' separation anxiety corresponded to a history of at least one exacerbation in the previous year. The influence of the parents' psychological well-being on the children's asthma control was previously unexplored. [ABSTRACT FROM AUTHOR]

Published
2024
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3. The Effects of Sacubitril/Valsartan on Clinical, Biochemical and Echocardiographic Parameters in Patients with Heart Failure with Reduced Ejection Fraction: The 'Hemodynamic Recovery'

Author

Diego Bellavia, Giuseppe Vitale, Eluisa La Franca, Filippo M. Sarullo, Francesco Clemenza, Giuseppe Romano, Laura Ajello, Salvatore Antonio Storniolo, Gabriele Di Gesaro, Giuseppa Caccamo, Egle Corrado, Calogero Falletta, Chiara Minà, Valentina Agnese, and Romano G, Vitale G, Ajello L, Agnese V, Bellavia D, Caccamo G, Corrado E, Di Gesaro G, Falletta C, La Franca E, Minà C, Storniolo SA, Sarullo FM, Clemenza F.

Subjects
medicine.medical_specialty, medicine.medical_treatment, heart failure, Hemodynamics, 030204 cardiovascular system & hematology, Article, Sacubitril, 03 medical and health sciences, 0302 clinical medicine, hemodynamic, Internal medicine, medicine, echocardiography, 030212 general & internal medicine, Enalapril, remodeling, Ejection fraction, business.industry, neprilysin inhibition, General Medicine, medicine.disease, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Valsartan, sacubitril/valsartan, Heart failure, Cardiology, reduced ejection fraction, Diuretic, business, Nt-ProBNP, Sacubitril, Valsartan, medicine.drug
Abstract

Background: Sacubitril/valsartan has been shown to be superior to enalapril in reducing the risks of death and hospitalization for heart failure (HF). However, knowledge of the impact on cardiac performance remains limited. We sought to evaluate the effects of sacubitril/valsartan on clinical, biochemical and echocardiographic parameters in patients with heart failure and reduced ejection fraction (HFrEF). Methods: Sacubitril/valsartan was administered to 205 HFrEF patients. Results: Among 230 patients (mean age 59 &plusmn, 10 years, 46% with ischemic heart disease) 205 (89%) completed the study. After a follow-up of 10.49 (2.93 &plusmn, 18.44) months, the percentage of patients in New York Heart Association (NYHA) class III changed from 40% to 17% (p &lt, 0.001). Median N&ndash, Type natriuretic peptide (Nt-proBNP) decreased from 1865 &plusmn, 2318 to 1514 &plusmn, 2205 pg/mL, (p = 0.01). Furosemide dose reduced from 131.3 &plusmn, 154.5 to 120 &plusmn, 142.5 (p = 0.047). Ejection fraction (from 27&plusmn, 5.9% to 30 &plusmn, 7.7% (p &lt, 0.001) and E/A ratio (from 1.67 &plusmn, 1.21 to 1.42 &plusmn, 1.12 (p = 0.002)) improved. Moderate to severe mitral regurgitation (from 30.1% to 17.4%, p = 0.002) and tricuspid velocity decreased from 2.8 &plusmn, 0.55 m/sec to 2.64 &plusmn, 0.59 m/sec (p &lt, 0.014). Conclusions: Sacubitril/valsartan induce &ldquo, hemodynamic recovery&rdquo, and, consistently with reduction in Nt-proBNP concentrations, improve NYHA class despite diuretic dose reduction.

Published
2019
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4. Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma

Author

Eugenio Baraldi, Valentina Agnese Ferraro, Silvia Carraro, and Stefania Zanconato

Subjects
Chronic rhinosinusitis, pediatric rhinosinusitis, lcsh:Medicine, Context (language use), Inflammation, Review, Periostin, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, nitric oxide, otorhinolaryngologic diseases, medicine, Exhaled breath condensate, 030212 general & internal medicine, Asthma, business.industry, lcsh:R, biological mediators, General Medicine, respiratory system, medicine.disease, respiratory tract diseases, pediatric asthma, 030228 respiratory system, chemistry, Exhaled nitric oxide, Immunology, medicine.symptom, business
Abstract

Background: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs). Conclusion: Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice.

Published
2019
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