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Start Over Author "Charline Miossec" Journal journal of clinical microbiology
2 results on '"Charline Miossec"'

1. Fungal Integrated Histomolecular Diagnosis Using Targeted Next-Generation Sequencing on Formalin-Fixed Paraffin-Embedded Tissues

Author

Alexis Trecourt, Meja Rabodonirina, Claire Mauduit, Alexandra Traverse-Glehen, Mojgan Devouassoux-Shisheboran, David Meyronet, Frédérique Dijoud, Christophe Ginevra, Emmanuelle Chapey-Picq, Emilie Josse, Patricia Martins-Simoes, Abderrazzak Bentaher, Damien Dupont, Charline Miossec, Florence Persat, Martine Wallon, Tristan Ferry, Félix Pham, Bruno Simon, and Jean Menotti

Subjects
Microbiology (medical)
Abstract

Histopathology is the gold standard for fungal infection (FI) diagnosis, but it does not provide a genus and/or species identification. The objective of the present study was to develop targeted next-generation sequencing (NGS) on formalin-fixed tissue samples (FTs) to achieve a fungal integrated histomolecular diagnosis.

Published
2023
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2. Fatal Invasive Infection with Fungemia Due to Microascus cirrosus after Heart and Lung Transplantation in a Patient with Cystic Fibrosis

Author

Patrice Le Pape, Dea Garcia-Hermoso, Charline Miossec, Michel Miegeville, Françoise Gay-Andrieu, Thierry Lepoivre, Alain Haloun, Michele Treilhaud, Florent Morio, François Leclair, Centre hospitalier universitaire de Nantes (CHU Nantes), Université de Nantes (UN), Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire (CNRMA), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), We are grateful to Francoise Dromer for fruitful discussions on the manuscript. We acknowledge Bernard Besse, Olivier Barre, and Damien Hoinard for technical assistance., and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, MESH: Histocytochemistry, MESH: Sequence Analysis, DNA, MESH: Fatal Outcome, Antifungal Agents, Cystic Fibrosis, medicine.medical_treatment, Case Reports, Cystic fibrosis, Echinocandins, chemistry.chemical_compound, Fatal Outcome, 0302 clinical medicine, MESH: Lipopeptides, Caspofungin, MESH: Immunocompromised Host, 030212 general & internal medicine, DNA, Fungal, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Fungemia, Microscopy, 0303 health sciences, Histocytochemistry, MESH: Heart Transplantation, MESH: Voriconazole, 3. Good health, MESH: Caspofungin, Microascus, Pleura, Radiography, Thoracic, MESH: Tomography, X-Ray Computed, Lung Transplantation, medicine.drug, Adult, Microbiology (medical), medicine.medical_specialty, MESH: Microscopy, MESH: Cystic Fibrosis, Molecular Sequence Data, MESH: Ascomycota, Biology, Immunocompromised Host, Lipopeptides, 03 medical and health sciences, MESH: Mycoses, Ascomycota, MESH: Fungemia, medicine, Humans, Lung transplantation, Voriconazole, MESH: Humans, MESH: Molecular Sequence Data, 030306 microbiology, MESH: Echinocandins, MESH: Adult, Sequence Analysis, DNA, Triazoles, MESH: Radiography, Thoracic, MESH: Antifungal Agents, medicine.disease, biology.organism_classification, Dermatology, MESH: Male, Surgery, MESH: DNA, Fungal, Transplantation, Pyrimidines, MESH: Pleura, Mycoses, MESH: Triazoles, chemistry, MESH: Pyrimidines, Scopulariopsis, Heart Transplantation, MESH: Lung Transplantation, Tomography, X-Ray Computed
Abstract

Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus , after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis / Microascus infections are discussed.

Published
2011
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