6 results on '"Gottlieb T"'
Search Results
2. Evaluation of E test as a rapid method for determining MICs for nutritionally variant streptococci
- Author
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Douglas, C P, primary, Siarakas, S, additional, and Gottlieb, T, additional
- Published
- 1994
- Full Text
- View/download PDF
3. Candida colonization as a risk marker for invasive candidiasis in mixed medical-surgical intensive care units: development and evaluation of a simple, standard protocol.
- Author
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Lau AF, Kabir M, Chen SC, Playford EG, Marriott DJ, Jones M, Lipman J, McBryde E, Gottlieb T, Cheung W, Seppelt I, Iredell J, and Sorrell TC
- Subjects
- Critical Illness, Diagnostic Tests, Routine methods, Humans, Intensive Care Units, Microbiological Techniques methods, Perineum microbiology, Pharynx microbiology, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Assessment, Sensitivity and Specificity, Urine microbiology, Candida isolation & purification, Candidiasis, Invasive diagnosis, Carrier State diagnosis, Diagnostic Tests, Routine standards, Microbiological Techniques standards
- Abstract
Colonization with Candida species is an independent risk factor for invasive candidiasis (IC), but the minimum and most practicable parameters for prediction of IC have not been optimized. We evaluated Candida colonization in a prospective cohort of 6,015 nonneutropenic, critically ill patients. Throat, perineum, and urine were sampled 72 h post-intensive care unit (ICU) admission and twice weekly until discharge or death. Specimens were cultured onto chromogenic agar, and a subset underwent molecular characterization. Sixty-three (86%) patients who developed IC were colonized prior to infection; 61 (97%) tested positive within the first two time points. The median time from colonization to IC was 7 days (range, 0 to 35). Colonization at any site was predictive of IC, with the risk of infection highest for urine colonization (relative risk [RR]=2.25) but with the sensitivity highest (98%) for throat and/or perineum colonization. Colonization of ≥2 sites and heavy colonization of ≥1 site were significant independent risk factors for IC (RR=2.25 and RR=3.7, respectively), increasing specificity to 71% to 74% but decreasing sensitivity to 48% to 58%. Molecular testing would have prompted a resistance-driven decision to switch from fluconazole treatment in only 11% of patients infected with C. glabrata, based upon species-level identification alone. Positive predictive values (PPVs) were low (2% to 4%) and negative predictive values (NPVs) high (99% to 100%) regardless of which parameters were applied. In the Australian ICU setting, culture of throat and perineum within the first two time points after ICU admission captures 84% (61/73 patients) of subsequent IC cases. These optimized parameters, in combination with clinical risk factors, should strengthen development of a setting-specific risk-predictive model for IC., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Published
- 2015
- Full Text
- View/download PDF
4. Molecular epidemiology of enterococcal bacteremia in Australia.
- Author
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Coombs GW, Pearson JC, Daley DA, Le T, Robinson OJ, Gottlieb T, Howden BP, Johnson PD, Bennett CM, Stinear TP, and Turnidge JD
- Subjects
- Anti-Bacterial Agents pharmacology, Australia epidemiology, Bacteremia microbiology, Coinfection epidemiology, Coinfection microbiology, Cross Infection epidemiology, Cross Infection microbiology, Drug Resistance, Bacterial, Enterococcus faecalis classification, Enterococcus faecalis genetics, Enterococcus faecium classification, Enterococcus faecium genetics, Genes, Bacterial, Gram-Positive Bacterial Infections microbiology, Humans, Microbial Sensitivity Tests, Molecular Epidemiology, Molecular Typing, Bacteremia epidemiology, Enterococcus faecalis isolation & purification, Enterococcus faecium isolation & purification, Gram-Positive Bacterial Infections epidemiology
- Abstract
Enterococci are a major cause of health care-associated infections and account for approximately 10% of all bacteremias globally. The aim of this study was to determine the proportion of enterococcal bacteremia isolates in Australia that are antimicrobial resistant, with particular emphasis on susceptibility to ampicillin and the glycopeptides, and to characterize the molecular epidemiology of the Enterococcus faecalis and Enterococcus faecium isolates. From 1 January to 31 December 2011, 1,079 unique episodes of bacteremia were investigated, of which 95.8% were caused by either E. faecalis (61.0%) or E. faecium (34.8%). The majority of bacteremias were health care associated, and approximately one-third were polymicrobial. Ampicillin resistance was detected in 90.4% of E. faecium isolates but was not detected in E. faecalis isolates. Vancomycin nonsusceptibility was reported in 0.6% and 36.5% of E. faecalis and E. faecium isolates, respectively. Unlike Europe and the United States, where vancomycin resistance in E. faecium is predominately due to the acquisition of the vanA operon, 98.4% of E. faecium isolates harboring van genes carried the vanB operon, and 16.1% of the vanB E. faecium isolates had vancomycin MICs at or below the susceptible breakpoint of the CLSI. Although molecular typing identified 126 E. faecalis pulsed-field gel electrophoresis pulsotypes, >50% belonged to two pulsotypes that were isolated across Australia. E. faecium consisted of 73 pulsotypes from which 43 multilocus sequence types were identified. Almost 90% of the E. faecium isolates were identified as CC17 clones, of which approximately half were characterized as ST203, which was isolated Australia-wide. In conclusion, the Australian Enterococcal Sepsis Outcome Programme (AESOP) study has shown that although they are polyclonal, enterococcal bacteremias in Australia are frequently caused by ampicillin-resistant vanB E. faecium.
- Published
- 2014
- Full Text
- View/download PDF
5. Comparative analysis of multidrug-resistant, non-multidrug-resistant, and archaic methicillin-resistant Staphylococcus aureus isolates from Central Sydney, Australia.
- Author
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Watson J, Givney R, Beard-Pegler M, Rose B, Merlino J, Vickery A, Gottlieb T, Bradbury R, and Harbour C
- Subjects
- Australia, Genotype, Humans, Methicillin Resistance, Microbial Sensitivity Tests, Phenotype, Staphylococcus aureus classification, Staphylococcus aureus genetics, Anti-Bacterial Agents pharmacology, Drug Resistance, Multiple, Staphylococcus aureus drug effects
- Abstract
In this study, the phenotypic and genotypic characteristics of 50 methicillin-resistant Staphylococcus aureus (MRSA) isolates (43 contemporary and 7 archaic strains from the mid-1960s) from four Sydney hospitals in the central Sydney area were compared. Phenotypic analysis based on antibiotic profiles and phage typing patterns categorized the MRSA isolates into three major groups: multidrug resistant (mMRSA), non-multidrug resistant (nmMRSA), and archaic. The nmMRSA isolates could be further subdivided into nmMRSA group 1, which was phage typeable and similar to the archaic group; nmMRSA group 2, which was non-phage typeable and only resistant to ciprofloxacin; and nmMRSA group 3, which was also nontypeable and generally resistant to other antibiotics. The characterization of all five phenotypic groups was then extended by genetic analysis. Restriction fragment length polymorphism (RFLP) analysis showed the 50 isolates could be sorted into 20 group-specific pulsotypes. mecI gene deletions and mutations at various percentages among the five MRSA groups were detected by sequencing. Several mec promoter mutations were also found. The overall findings indicated that nmMRSA strains may have independently acquired mec DNA and are more likely to be newly emergent strains than nmMRSA variants.
- Published
- 2003
- Full Text
- View/download PDF
6. Multicenter evaluation of the Abbott LCx Mycobacterium tuberculosis ligase chain reaction assay.
- Author
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Lumb R, Davies K, Dawson D, Gibb R, Gottlieb T, Kershaw C, Kociuba K, Nimmo G, Sangster N, Worthington M, and Bastian I
- Subjects
- Humans, Sensitivity and Specificity, DNA Ligases, Gene Amplification, Mycobacterium tuberculosis isolation & purification
- Abstract
Four Australian hospital laboratories evaluated the performance of the Abbott LCx Mycobacterium tuberculosis assay with 2,347 specimens (2,083 respiratory and 264 nonrespiratory specimens) obtained from 1, 411 patients. A total of 152 specimens (6.5%) were culture positive for Mycobacterium tuberculosis complex (MTBC); of these, 79 (52%) were smear positive. After resolution of discrepant data, the overall sensitivity, specificity, and positive and negative predictive values for the LCx assay were 69.7, 99.9, 99.1, and 97.7% respectively. For smear-positive respiratory specimens that were culture positive for MTBC, the values were 98.5, 100, 100, and 98.4%, respectively, while the values for smear-negative respiratory specimens were 41.5, 99.9, 96.4, and 98%, respectively. Relative operating characteristic curves were constructed to demonstrate the relationship between sensitivity and specificity for a range of possible cutoff values in the LCx assay. These graphs suggested that the assay sensitivity for respiratory samples could be increased from 70.2 to 78.6%, while the specificity would be reduced from 99.9 to 99.4% by inclusion of a grey zone (i.e., LCx assay values of between 0.2 and 0.99). An algorithm is presented for the handling of specimens with LCx assay values within this grey zone.
- Published
- 1999
- Full Text
- View/download PDF
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