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Your search keyword '"Mackow, E. R."' showing total 4 results
Start Over Author "Mackow, E. R." Journal journal of clinical microbiology
4 results on '"Mackow, E. R."'

4. New York 1 and Sin Nombre viruses are serotypically distinct viruses associated with hantavirus pulmonary syndrome.

Author

Gavrilovskaya I, LaMonica R, Fay ME, Hjelle B, Schmaljohn C, Shaw R, and Mackow ER

Subjects
Animals, Antigens, Viral blood, Chlorocebus aethiops, Orthohantavirus immunology, Hantavirus Pulmonary Syndrome blood, Hantavirus Pulmonary Syndrome immunology, Hantavirus Pulmonary Syndrome pathology, Humans, Nucleocapsid Proteins analysis, Nucleocapsid Proteins immunology, Peromyscus, Serotyping, Vero Cells, Orthohantavirus classification, Hantavirus Pulmonary Syndrome virology
Abstract

New York 1 virus (NY-1) and Sin Nombre virus (SN) are associated with hantavirus pulmonary syndrome (HPS). NY-1 and SN are derived from unique mammalian hosts and geographic locations but have similar G1 and G2 surface proteins (93 and 97% identical, respectively). Focus reduction neutralization assays were used to define the serotypic relationship between NY-1 and SN. Sera from NY-1-positive Peromyscus leucopus neutralized NY-1 and SN at titers of >/=1/3,200 and 16-fold-lower neutralizing titers to NY-1 than to SN. Reference sera to Hantaan, Seoul, and Prospect Hill viruses also failed to neutralize NY-1. These results indicate that SN and NY-1 define unique hantavirus serotypes and implicate the presence of additional HPS-associated hantavirus serotypes in the Americas.

Published
1999
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