1. Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment.
- Author
-
Desnos-Ollivier M, Moquet O, Chouaki T, Guérin AM, and Dromer F
- Subjects
- Aged, Amino Acid Substitution genetics, Antifungal Agents administration & dosage, Caspofungin, DNA Mutational Analysis, DNA, Fungal chemistry, DNA, Fungal genetics, Echinocandins administration & dosage, Glucosyltransferases genetics, Humans, Lipopeptides, Male, Molecular Sequence Data, Mutation, Missense, Sequence Analysis, DNA, Antifungal Agents pharmacology, Drug Resistance, Fungal, Echinocandins pharmacology, Mycoses drug therapy, Mycoses microbiology, Saccharomycetales drug effects
- Abstract
Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C. lusitaniae isolates was observed during caspofungin treatment. This resistance resulted from missense mutation in the echinocandin target Fks1 gene.
- Published
- 2011
- Full Text
- View/download PDF