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Start Over Author "Laxman Desai" Journal journal of clinical oncology
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1. In vitro characterization and in vivo efficacy of NEOS-518, a novel isoquinoline embedded amino oxazole, that demonstrates CDK-1,2, 3, and 9 inhibition

Author

Roseanne Wexler, Sara Anne Little, Laxman Desai, Timothy Murphy, and Sumathi Chittamuru

Subjects
Cancer Research, biology, business.industry, Kinase, Cell cycle, In vitro, Cell biology, chemistry.chemical_compound, Oncology, chemistry, In vivo, Cyclin-dependent kinase, biology.protein, Medicine, Malignant cells, Isoquinoline, business, Oxazole
Abstract

e14509Background: Cyclin dependent kinases (CDK) play a vital role in cell cycling and proliferation. Altered expression of these kinases in malignant cells results in deregulation of cell cycle ac...

Published
2018
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