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Start Over Author "Pope FM" Journal journal of clinical pathology
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4. Osteogenesis imperfecta (lethal) bones contain types III and V collagens.

Author

Pope FM, Nicholls AC, Eggleton C, Narcissi P, Hey EN, and Parkin JM

Subjects
Electrophoresis, Polyacrylamide Gel, Femur embryology, Gestational Age, Humans, Infant, Newborn, Male, Collagen analysis, Femur analysis, Osteogenesis Imperfecta metabolism
Abstract

Lethal osteogenesis imperfecta (OI-L) and normal fetal bones contain types I and V collagen with relatively more type V in OI-L bones. The latter, unlike normal fetal bone, also contain some type III collagen. Such altered collagen ratios could directly produce the bony fragility and radiotranslucency of OI-L bones. Since this is an inherited osteoporosis similar alterations in acquired osteoporoses are also possible.

Published
1980
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