1. Periodontal diseases and carotid intima-media thickness in Bangladesh.
- Author
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Wu, Fen, Chen, Yu, Demmer, Ryan T., Parvez, Faruque, Paul, Rina Rani, Shaheen, Ishrat, Sarwar, Golam, Ahmed, Alauddin, Eunus, Mahbub, Ahsan, Nafiz, Habibullah, Nur Mohammad, Islam, Tariqul, Rundek, Tatjana, Ahsan, Habibul, and Desvarieux, Moise
- Subjects
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ATHEROSCLEROSIS risk factors , *ANALYSIS of variance , *CHI-squared test , *CONFIDENCE intervals , *PERIODONTAL disease , *PROBABILITY theory , *RESEARCH funding , *MULTIPLE regression analysis , *CROSS-sectional method , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *DISEASE complications - Abstract
Aim To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population. Methods We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness ( IMT). Results Mean attachment loss ( AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0- μm (95% CI: 2.2, 37.8) and 26.5- μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 ( p < 0.05) and soluble intercellular adhesion molecule-1 ( p < 0.01). Conclusions Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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