1. Trimipramine in physical illness with depression.
- Author
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Rifkin A, Reardon G, Siris S, Karagji B, Kim YS, Hackstaff L, and Endicott N
- Subjects
- Adjustment Disorders complications, Adjustment Disorders drug therapy, Adjustment Disorders psychology, Ambulatory Care, Clinical Trials as Topic, Depressive Disorder etiology, Depressive Disorder psychology, Disease psychology, Double-Blind Method, Female, Humans, Male, Middle Aged, Outcome and Process Assessment, Health Care, Personality Inventory, Placebos, Psychiatric Status Rating Scales, Psychotherapy, Brief, Depressive Disorder drug therapy, Dibenzazepines therapeutic use, Disease complications, Trimipramine therapeutic use
- Abstract
To assess whether tricyclic antidepressants are useful in patients with a serious physical disorder who develop symptoms of major depression, 42 medically ill outpatients who met RDC criteria for endogenous major depression and had a Raskin depression score of at least 7 were studied. The patients were randomly assigned to a 6-week trial of trimipramine or placebo under double-blind conditions. In the placebo group, depressive symptoms improved when the physical disorder improved; in the trimipramine group, improvement was seen in the depressive symptoms even when there was no concomitant improvement in physical condition.
- Published
- 1985