1. CTLA-4 (+49A/G) Polymorphism and Type-1 Diabetes in Turkish Children.
- Author
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Çelmeli, Fatih, Türkkahraman, Doğa, Özel, Deniz, Akçurin, Sema, and Yeğin, Olcay
- Subjects
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TYPE 1 diabetes , *DIABETES in children , *GENETIC polymorphisms , *CHILDREN , *ANTIGENS - Abstract
Objective: To evaluate the contribution of cytotoxic T-Iymphocyte antigen-4 (CTLA-4)+49A/G polymorphism to the susceptibility to type-1 diabetes (T1D) in Turkish children. Methods: A case-control study was designed to include 91 Turkish children with T1D and 99 healthy controls. CTLA-4 (+99A/G) gene polymorphism typing was done by PCR amplification followed by restriction fragment length polymorphism method. Results: The genotype and allele frequencies of the CTLA-4 (+99A/G) polymorphism in patients with T1D were not different from those in the controls (p>0.05). The allele frequency of G was 36.2% in patients with T1D, and 31.8% in controls (p>0.05). Additionally, this polymorphism was not associated with the clinical and laboratory characteristics of the patients with T1D (p>0.05). Conclusions: Our case-control study suggests that the CTLA-4 (+99A/G) gene polymorphism is not associated with T1D in the Turkish population. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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