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Efficiency is one of the most important criteria in departments responsible for the production of compounds in a library format. Consequently, this was a key factor in the initial design of our automated medicinal chemistry department, established some years ago. Nonetheless, we were able to improve and optimize our workflows and processes constantly. Here, we outline our current setup, from design to submission of libraries, and discuss which procedures and techniques appear to be useful for us and which ones turned out to be less effective. The aim of the manuscript is not to present individualized and tailor-made solutions in our laboratory but rather to describe approaches (often executed with commercial equipment) which might be of relevance for a broader readership working in this field.