1. FaST-LMM for Two-Way Epistasis Tests on High-Performance Clusters.
- Author
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Martínez H, Barrachina S, Castillo M, Quintana-OrtÍ ES, Rambla de Argila J, Farré X, and Navarro A
- Subjects
- Algorithms, Humans, Bipolar Disorder genetics, Computational Biology methods, Computer Simulation, Epistasis, Genetic, Models, Genetic, Polymorphism, Single Nucleotide, Software
- Abstract
We introduce a version of the epistasis test in FaST-LMM for clusters of multithreaded processors. This new software maintains the sensitivity of the original FaST-LMM while delivering acceleration that is close to linear on 12-16 nodes of two recent platforms, with respect to improved implementation of FaST-LMM presented in an earlier work. This efficiency is attained through several enhancements on the original single-node version of FaST-LMM, together with the development of a message passing interface (MPI)-based version that ensures a balanced distribution of the workload as well as a multigraphics processing unit (GPU) module that can exploit the presence of multiple GPUs per node.
- Published
- 2018
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