1. Gadoxetic Acid–Enhanced Hepatobiliary-Phase Magnetic Resonance Imaging for Delineation of Focal Nodular Hyperplasia
- Author
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Anne Berger, Tim Frederik Weber, Theresa Mokry, Philipp Mayer, Viktoria Palm, Thomas Longerich, Hans-Ulrich Kauczor, Karl Heinz Weiss, and Ruofan Sheng
- Subjects
Adult ,Gadolinium DTPA ,Male ,Gadoxetic acid ,Contrast Media ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Flip angle ,Image Processing, Computer-Assisted ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Focal nodular hyperplasia ,Magnetic resonance imaging ,Image Enhancement ,medicine.disease ,Magnetic Resonance Imaging ,Liver ,Focal Nodular Hyperplasia ,030220 oncology & carcinogenesis ,Hepatobiliary phase ,Female ,business ,Nuclear medicine ,medicine.drug - Abstract
OBJECTIVE The aim of this study was to investigate whether hepatobiliary-phase (HBP) flip-angle (FA) increase to 25° improves conspicuity of focal nodular hyperplasia (FNH) and enables HBP delay reduction. METHODS This was a retrospective study of 23 patients with 46 FNHs. In each patient, HBP was performed with reduced-delay high FA (early/high), standard-delay high FA (late/high), and standard-delay standard FA (standard). Relative enhancement of liver and FNH periphery, FNH periphery-to-liver contrast ratio, and FNH periphery-to-central scar contrast ratio were compared between each HBP. RESULTS Early/high, late/high, and standard HBPs were performed after 13.00 ± 2.12, 19.12 ± 3.10, and 19.68 ± 3.22 minutes, respectively. Liver and FNH periphery relative enhancement, FNH periphery-to-liver contrast ratio, and FNH periphery-to-central scar contrast ratio were higher for early/high and late/high than for standard HBP (P < 0.001 to P = 0.0048). CONCLUSIONS Increasing FA to 25° improves delineation of FNHs in HBP. Combining FA increase with delay reduction is superior to standard HBP and is sufficient for FNH characterization.
- Published
- 2018
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