1. Dual pancreas- and lung-targeting therapy for local and systemic complications of acute pancreatitis mediated by a phenolic propanediamine moiety.
- Author
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Li, Jianbo, Zhang, Jinjie, Fu, Yao, Sun, Xun, Gong, Tao, Jiang, Jinghui, and Zhang, Zhirong
- Subjects
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TARGETED drug delivery , *LUNG physiology , *PANCREATITIS treatment , *PROPANEDIAMINE , *DISEASE complications , *DRUG delivery systems - Abstract
To inhibit both the local and systemic complications with acute pancreatitis, an effective therapy requires a drug delivery system that can efficiently overcome the blood–pancreas barrier while achieving lung-specific accumulation. Here, we report the first dual pancreas- and lung-targeting therapeutic strategy mediated by a phenolic propanediamine moiety for the treatment of acute pancreatitis. Using the proposed dual-targeting ligand, an anti-inflammatory compound Rhein has been tailored to preferentially accumulate in the pancreas and lungs with rapid distribution kinetics, excellent tissue-penetrating properties and minimum toxicity. Accordingly, the drug–ligand conjugate remarkably downregulated the proinflammatory cytokines in the target organs thus effectively inhibiting local pancreatic and systemic inflammation in rats. The dual-specific targeting therapeutic strategy may help pave the way for targeted drug delivery to treat complicated inflammatory diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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