1. Syntheses, urease inhibition activities, and fluorescent properties of transition metal complexes.
- Author
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Qiu, Xiaoyang, Wang, Jing, Shi, Dahua, Li, Suzhi, Zhang, Fuli, Zhang, Fuqiang, Cao, Guangxiu, and Zhai, Bin
- Subjects
TRANSITION metal complexes ,COMPLEX compounds synthesis ,SCHIFF bases ,UREASE ,ENZYME inhibitors ,CRYSTAL structure ,METAL ions ,X-ray diffraction - Abstract
Four transition metal complexes with Schiff base and 1,10-phenanthroline, [Cu(L)(phen)]2·C2H5OH (1), [Zn(L)(phen)]2·C2H5OH (2), [Ni(L)(phen)]2·C2H5OH (3), and [Co(L)(phen)]2·C2H5OH (4) (H2L = 1-((2-hydroxynaphthalen-1-yl)methylene)thiosemicarbazide; phen = 1,10-phenanthroline) were synthesized and characterized by physico-chemical methods. The crystal structure of1was determined by X-ray single-crystal diffraction analysis.1crystallizes in the orthorhombic space groupPbcawitha = 15.008(9),b = 16.100(10),c = 37.54(2) Å,V = 9070(10) Å3,Z = 8,GOOF = 1.002,R1 = 0.0626, andwR2 = 0.0912. The fluorescence and urease inhibitory activities of the compounds were tested. The enzymatic activity study indicated that3possessed potent inhibition againstjack beanurease, with IC50 = 1.2 ± 0.1 μM, and about 35 times more than 42.1 ± 0.4 acetohydroxamic acid as positive reference. This suggests that inhibitory efficiency of these complexes can be strongly influenced by different transition metal ions. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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