Search

Background: The stratum corneum plays an important protective physiological role in providing a barrier to preventing skin desiccation and penetration of external agents. Emollients are used commonly to improve barrier function and skin hydration. Aims: The primary objective of this study was to evaluate the effect of an emollient, V0034CR cream, and its active ingredients, to restore the cutaneous barrier. Secondary objectives included assessment of the moisturizing activity of each product and tolerance. The study was not designed to evaluate therapeutic benefit. Methods: In this randomized, double‐blind, 4‐arm crossover, clinical pharmacology study, the full emollient V0034CR, its vehicle formulation alone, or with glycerol, or petrolatum, was applied to the forearms of healthy volunteers (n = 51) with dry skin (Kligman score of 2 or 3). Cutaneous permeability by Trans Epidermal Water Loss (TEWL) and skin moisture content by corneometry were serially measured for 12 hours following application. An analysis of variance with repeated measures was performed on the evolution of TEWL and corneometry. Results: V0034CR emollient significantly reduced mean TEWL compared to vehicle (P =.0018) and vehicle + glycerol (P =.0001) and significantly increased mean corneometry scores compared to vehicle (P <.0001) and vehicle + petrolatum (P <.0001). Conclusions: The emollient V0034CR presented combined effects, with the petrolatum component improving skin barrier function, with a reduction in TEWL, and the glycerol component improving skin hydration. [ABSTRACT FROM AUTHOR]

Background: Emollients play a key role in the treatment of eczematous lesions and xerosis such as in atopic dermatitis. However, studies that show the actual benefits of cleansers are few and far between. Aims: This study aims to evaluate the tolerance and efficacy of a high‐emollient liquid cleanser (HELC) designed for very dry and atopic‐prone skin, in the absence of any additional skin care. The product is a soap‐free and fragrance‐free liquid cleanser, containing mild surfactants and a ternary system of selected emollients: glycerin, vaseline, and paraffin. Methods: In‐use study was conducted under dermatological, pediatric, and ophthalmological supervision in 50 subjects (infants, children, and adults) with "dry to very dry and atopic‐prone" skin. The primary objective of this monocentric, open, and intra‐individual study was to assess the dermatological and ophthalmological tolerance of HELC after 21 days of using it at least once a day on the face and body. The secondary objectives were to evaluate its efficacy based on a clinical score (SCORAD), assess its short‐ and long‐term moisturizing effect by measuring hydration rates (Corneometer®), and ascertain its cosmetic acceptability through a subjective evaluation questionnaire. Results: The study validates the good dermatological and ophthalmological tolerance of HELC. Its efficacy was demonstrated by improvements in the SCORAD and moisturizing scores. Furthermore, the product was very well accepted by the subjects. Conclusion: The fragrance‐free HELC tested in this study for 21 days on "dry to very dry and atopic‐prone skin" improves skin dryness and pruritus while ensuring good tolerance. [ABSTRACT FROM AUTHOR]