1. Comparative study of tramadol combined with dexamethasone and diclofenac sodium in third-molar surgery
- Author
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Luiz Carlos Ferreira da Silva, Thiago de Santana Santos, Laerte Ribeiro Menezes Júnior, José Renato Moraes Carvalho Barreto Brandão, Jadson Alípio Santana de Sousa Santos, and Ana Carla de Assunção Oliveira
- Subjects
Adult ,Male ,Diclofenac ,Adolescent ,Visual analogue scale ,Premedication ,Anti-Inflammatory Agents ,Administration, Oral ,Dexamethasone ,Young Adult ,Postoperative Complications ,Double-Blind Method ,medicine ,Edema ,Humans ,Range of Motion, Articular ,Tramadol ,Acetaminophen ,Pain Measurement ,Pain, Postoperative ,Cross-Over Studies ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Tooth, Impacted ,Diclofenac Sodium ,Analgesics, Non-Narcotic ,Crossover study ,Analgesics, Opioid ,Drug Combinations ,Otorhinolaryngology ,Anesthesia ,Tooth Extraction ,Female ,Molar, Third ,Surgery ,Oral Surgery ,business ,Follow-Up Studies ,medicine.drug - Abstract
The aim of this randomized, double-blind clinical trial was to investigate the effect of preemptive analgesia with a combination of tramadol+dexamethasone or tramadol+diclofenac sodium. The study included 30 patients (age range: 16-30 years), who were randomly assigned to 2 groups by the split-mouth method. Postoperative pain was assessed with a visual analogue scale at 4, 6, 12, 24, and 48 h postoperatively (p.o.h.). Swelling was measured at 48 p.o.h. Maximal interincisor distance was measured at 48 p.o.h. and 7 postoperative days (p.o.d.). Significant differences in postoperative pain intensity were detected between the drug combinations at 4, 6, and 12p.o.h., suggesting the importance of preemptive analgesia. Patients treated with tramadol+dexamethasone showed lower pain scores compared to the tramadol+diclofenac sodium combination, larger postoperative mouth opening, and less swelling. The tramadol+dexamethasone combination also was more effective than tramadol+diclofenac sodium at reducing inflammation.
- Published
- 2012
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