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Your search keyword '"Elaine R. Nimmo"' showing total 3 results
Start Over Author "Elaine R. Nimmo" Journal journal of crohn's and colitis
3 results on '"Elaine R. Nimmo"'

1. P846 Genetics, methylation, and disease state interact at the VMP1/MIR21 locus

Author

J. Satsangi, Elaine R. Nimmo, Alex Adams, Nicholas T. Ventham, and KR O’Leary

Subjects
Genetics, 03 medical and health sciences, 0302 clinical medicine, business.industry, Gastroenterology, Medicine, 030211 gastroenterology & hepatology, Locus (genetics), 030212 general & internal medicine, General Medicine, Methylation, Disease, business
Published
2018
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2. DOP082. Proximity extension assay immunoassay technology identifies novel serum biomarkers that can diagnose and classify inflammatory bowel diseases: IBD Character Consortium

Author

Morten H. Vatn, Jørgen Jahnsen, Daniel Bergemalm, Nicholas T. Ventham, Fernando Gomollón, Elaine R. Nimmo, Simen Vatn, Fredrik A. Dahl, R. Kalla, Hazel E. Drummond, David C. Wilson, Henrik Hjortswang, Petr Ricanek, Jonas Halfvarson, Marie J. Pierik, Johan D. Söderholm, Cecilia Petren, Jonas Christoffer Lindstrøm, Jack Satsangi, Niklas Nordberg, Erik Pettersson, Nicholas A. Kennedy, and Anette Ocklind

Subjects
0301 basic medicine, medicine.diagnostic_test, business.industry, fungi, Gastroenterology, food and beverages, Inflammatory Bowel Diseases, General Medicine, digestive system diseases, 03 medical and health sciences, 030104 developmental biology, Character (mathematics), Serum biomarkers, Immunoassay, Immunology, Medicine, business
Abstract

Proximity extension assay immunoassay technology identifies novel serum biomarkers that can diagnose and classify inflammatory bowel diseases : IBD Character Consortium

Published
2016
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3. DOP010 Epigenome-wide analysis in childhood-onset Crohn's disease implicates MIR21 in pathogenesis and identifies multiple methylation-based diagnostic biomarkers

Author

Richard K Russell, Georgina L. Hold, Elaine R. Nimmo, Nicholas T. Ventham, Alex Adams, David C. Wilson, Jack Satsangi, Emad M. El-Omar, Nicholas A. Kennedy, R Hansen, Colin L. Noble, KR O’Leary, and Hazel E. Drummond

Subjects
Crohn's disease, business.industry, Gastroenterology, FOXP3, General Medicine, Methylation, Epigenome, medicine.disease, Phenotype, Pathogenesis, Cancer research, Medicine, Immunohistochemistry, Tumor necrosis factor alpha, business
Abstract

in the CD4+aEb7 compartment (p < 0.001). IL-10 was not differentially expressed between CD4+aEb7+ and CD4+aEb7 lymphocytes in controls or UC, and a low frequency of aEb7+FOXP3+ cells was observed by IHC. qPCR array confirmed higher mRNA levels of IFNg (p < 0.001), TNFa (p < 0.01) and IL-17A (p < 0.01), and lower transcription of FOXP3 (p < 0.0001) in CD4+aEb7+ cells compared to CD4+aEb7 cells. Conclusions: aEb7 expression was associated with an enrichment of pro-inflammatory Th17, Th1 and Th17/Th1 T lymphocytes, and not associated with a regulatory phenotype. These data suggest therapeutic interventions targeting aE expressing T cells and the aEb7 integrin itself may be viable approaches for reducing aberrant inflammatory responses in UC.

Published
2014
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