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• Historic center of Naples is one of the UNESCO word heritage sites. • Cathedrals, churches and chapels are subject to cavity collapse. • Places of worship are above a connected network of underground cavities. • DInSAR analysis suggest the presence of anomalous areas. • 95 places of worship of the historic center of Naples are susceptible to sinkholes. The historic center of Naples (southern Italy) is characterized by a variety of elements which, forming its cultural asset, have contributed to its recognition as a UNESCO World Heritage site. Among these, cathedrals, churches and chapels are particularly relevant due to their diffusion and differentiation in age. A singular feature of these places of worship is the presence of a frequently connected network of underground cavities. Such cavities, excavated for quarrying tuff blocks, are susceptible to sudden collapses generating sinkholes which in a number of cases have been responsible for the loss of human lives. On this basis and considering the importance of such elements as attractors of visitors, an analysis of susceptibility to sinkholes of cathedrals, churches and chapels has been here carried out. A sinkhole, cavities and places of worship inventory was prepared using available data and was used, in association to ongoing ground deformation data obtained by DInSAR. Results indicated that 40% of the inventoried sinkholes are a product of cavity collapses and in 45 cases cavities lie underneath places of worship. Geodetic data obtained by Differential Interferometric SAR technique indicate that approximately 1 km2 of the historic center of Naples is subject to ongoing subsiding deformation that in several cases is localized above cavities. The susceptibility map derived from available data indicate the presence of a zone where no cathedral, church and chapel can be subject to sinkholes (1) and 3 zones where they can be subject to sagging (2), potential future cavity collapses (3) and future cavity collapses anticipated by ongoing deformation (4); in detail, 34 places of worship are in zone 2, 57 in zone 3 and 9 in zone 4. Considering an increasing susceptibility level of the identified zones, the 9 places of worship located in zone 4 require a quick response in terms of characterization, stability analysis and real time monitoring have been identified. [ABSTRACT FROM AUTHOR]