1. Intermittent versus continuous terbinafine in the treatment of toenail onychomycosis: A randomized, double‐blind comparison.
- Author
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Sigurgeirsson, Bardur, Elewski, Boni E., Rich, Phoebe A., Opper, Carol, Cai, Bin, Nyirady, Judit, and Bakshi, Rajesh
- Subjects
TERBINAFINE ,ANTIFUNGAL agents ,ONYCHOMYCOSIS ,NAIL diseases ,CLINICAL medicine ,METHYLNAPHTHALENES - Abstract
Background : Terbinafine is an established drug for the treatment of toenail onychomycosis. Minimizing the total dose of terbinafine and giving it intermittently could improve tolerability as well as compliance, provided efficacy is not compromised. Objective : Two identical trials were conducted to compare the efficacy, safety and tolerability of the current standard regimen of terbinafine 250 mg daily with a new formulation of terbinafine given intermittently for three cycles of 2 weeks of treatment (350 mg daily) followed by 2 weeks off treatment. Methods : A total of 2005 patients with a clinical diagnosis of subungual onychomycosis of the large toenail confirmed by microscopy and culture for a dermatophyte were recruited into the two trials and treated for 12 weeks. Results : Patients with onychomycosis of prolonged duration (mean 9 years) and a median nail involvement of 63% with or without spikes, lateral involvement and white superficial onychomycosis (WSO) were included in the trial. The studies found a significant difference ( p [ABSTRACT FROM AUTHOR]
- Published
- 2006
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