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Background: No topical and systemic treatment is proven to be effective on Cutaneous Macular Amyloidosis (CMA). The physical removal of the deposited protein by lasers may be a better choice., Objective: To compare the efficacy of different lasers including Pulsed dye laser (PDL), 1064 mode of Q-Switched Nd-YAG, CO 2 , and combined CO 2 and Q-Switched Nd:YAG lasers for the treatment of CMA., Patients and Method: 17 adult female patients with clinical CMA and histopathological confirmation were included in this study. Four close 1 by 1 cm 2 areas were treated simultaneously with PDL, Q-Switched Nd-YAG, CO 2 and combined CO 2 and Nd-YAG Lasers. The energy used for 585 nm PDL were 9 J/cm 2 with the spot size of 5 mm. The energy used for 1064 nm mode of Nd-YAG laser was 5 Joules/cm 2 , with the spot size of 4 mm, and the frequency of 10 hertz. The energies used for CO 2 laser were 4 and 3.5 Micro Joules for the first and second Passes., Results: No desirable result obtained after PDL therapy. The Q-Switched Nd-YAG was effective in only 3 patients. All areas treated with CO 2 laser were cleared., Conclusion: The CO 2 laser is seems to be the most effective laser treatment of CMA.

Background: The regeneration or revascularization of blood vessels after pulsed dye laser (PDL) treatment is one of the causes of treatment failures of cutaneous capillary malformations (CM). Recently, topical administration of rapamycin was introduced as a possible adjunctive therapeutic option to minimize postlaser revascularization in facial CM., Objectives: We evaluated the effect of combined use of 1% topical rapamycin with PDL compared to PDL alone in cutaneous CM of trunk or extremities and tried to identify the optimal duration of topical rapamycin application., Methods: Three adjacent areas of cutaneous CM that had never been treated before were selected in each patient and underwent the following regimens: (A) PDL + vehicle for 8 weeks post-PDL; (B) PDL + topical rapamycin for 1-week post-PDL and (C) PDL + topical rapamycin for 8 weeks post-PDL. Each test site was treated by PDL for two sessions with 8 weeks interval., Results: Only one of six patients showed clinical improvement with combined rapamycin treatment. Overall, there was no statistically significant difference in erythema and blanching rate among PDL alone and combined rapamycin regimens., Conclusion: One percent topical rapamycin does not seem to be effective as a treatment modality for cutaneous CM of trunk or extremities.

Background: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). But the treatment of recalcitrant warts is still challenging., Objective: In this study, we compared the effectiveness of pulsed dye laser (PDL) and long pulsed Nd:YAG (LPNY) laser in the treatment of recalcitrant viral warts., Methods: We retrospectively analyzed the medical records of patients with recalcitrant warts treated with laser therapy between January 2013 and February 2016., Results: Seventy-two patients with recalcitrant warts were evaluated. Thirty-nine patients were treated with pulsed dye laser and thirty-three patients were treated with LPNY laser. The following parameters were used: PDL (spot size, 7 mm; pulse duration, 1.5 ms; and fluence, 10-14 J/cm 2 ) and LPNY (spot size, 5 mm; pulse duration, 20 ms; and fluence, 240-300 J/cm 2 ). Complete clearance of two patients (5.1%) in PDL group, and three patients (9.1%) in LPNY group were observed without significant side effects. The patients who achieved at least 50% improvement from baseline were 20 (51.3%) in PDL and 22 (66.7%) in LPNY, respectively., Conclusion: This research is meaningful because we compared the effectiveness of the PDL and LPNY in the recalcitrant warts. Both PDL and LPNY laser could be used as a safe and alternative treatment for recalcitrant warts.

Unlabelled: Abstract Background: The 595 nm tunable pulsed dye laser has been used in China for more than 10 years. However, no studies about its effect and side-effect in treatment of superficial hemangioma have been documented., Objective: This study was designed to retrospectively summarize its usage in Chinese patients., Methods: Infant patients with superficial hemangioma, who had received 595 nm tunable pulsed dye laser treatment in our laser center in the last 10 years, were recruited. Detailed demographics, results of assessment about their degree of clearance and clinical examination for treatment complications were entered into SASS10.0 version database, and statistical analyses were conducted., Results: Six hundred and fifty-seven cases with superficial hemangioma were recruited. The overall effectiveness rate was 91.17%. Female patients respond better than male, the difference was statistically significant (p<0.001). Lesions at different part of the body respond differently to the treatment with lesions on extremities show the best result. The response rate does not increase with time of treatments. The most common side-effects were pigment changes and skin atrophy, which usually resolve spontaneously and disappear completely in a few months., Conclusions: Our experience confirmed the satisfactory clinical efficacy and safety of the 595 nm tunable pulse dye laser in the treatment of childhood superficial hemangioma.

Objectives: Recent studies have demonstrated that pulsed-dye laser (PDL) treatment is beneficial for inflammatory acne treatment. However, persistent erythema after inflammatory acne vulgaris ('acne erythema') remains a therapeutic challenge. The objectives of this study were to evaluate the clinical efficacy and safety of a long pulse duration 595-nm PDL (V-beam laser) therapy for the treatment of acne erythema., Methods: Twenty patients with acne erythema were treated using two successive sessions with a 595-nm PDL at 4-week intervals. Overall acne severities were assessed using Leeds scores, degree of improvement using standardized digital photographs, erythema indexes and skin elasticity findings at baseline, and 4 weeks after each treatment. Patients' self-assessments were also recorded., Results: A total of 90% of acne erythema patients achieved clinical improvement. Lesion counts decreased 24.9% after the first treatment (p<0.05) and by 57.6% (versus baseline) after the second treatment (p<0.05). Significant improvements were also noted in mean Leeds scores, erythema indexes, and skin elasticities after each treatment. Treatment-related pain was well-tolerated and adverse effects were limited to transient erythema and edema at treatment sites., Conclusion: A long pulse duration 595-nm PDL was found to improve acne erythema with minimal discomfort and an increase in skin elasticity.