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Objectives: To assess the burden of chronic Non-communicable diseases (NCDs) such as diabetes and hypertension, and evaluate the utilization of drugs for their treatment among the population of Andhra Pradesh, India., Methods: A cross-sectional study was conducted to analyse the prevalence of diabetes and hypertension, as well as the pattern of drug usage for their management. Data were collected through surveys and medical records review., Results: The study revealed a high prevalence of diabetes and hypertension in Andhra Pradesh, with significant proportions of the population remaining untreated despite critical drug utilization. Commonly used antidiabetic drugs included metformin, glipizide, and insulin, while telmisartan, furosemide, and metoprolol were frequently utilized for hypertension treatment. Side effects associated with these drugs were reported, emphasizing the need for better public awareness campaigns, improved access to healthcare, and effective management of side effects., Conclusions: The findings underscore the importance of early detection and preventive measures for hypertension and diabetes. There is a pressing need for tailored interventions addressing social and economic factors contributing to non-adherence to treatment regimens. While the widespread use of medications indicates significant awareness and proactive healthcare among a substantial portion of the population, the presence of individuals not adhering to their treatment suggests significant gaps in awareness and access to healthcare services. This study provides crucial insights into medication patterns for managing diabetes and hypertension in Andhra Pradesh, laying the groundwork for targeted public health interventions., Competing Interests: Conflict of interestNo conflict of interest in the manuscript., (© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)