7 results on '"Toshiaki, Ohkuma"'
Search Results
2. Onset of type 1 diabetes during bone growth period is associated with increased prevalence of bone fracture: A post‐hoc analysis of a cross‐sectional study
- Author
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Yuji Komorita, Masae Minami, Yasutaka Maeda, Rie Kishita, Toshiaki Ohkuma, and Takanari Kitazono
- Subjects
Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Published
- 2022
- Full Text
- View/download PDF
3. Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin‐treated type 2 diabetes: The Fukuoka Diabetes Registry
- Author
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Masanori Iwase, Yuji Komorita, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, and Takanari Kitazono
- Subjects
Adiponectin ,Hypoglycemia ,Insulin ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims/Introduction The incidence of severe hypoglycemia and its risk factors including an insulin‐sensitizing adipokine, adiponectin, were prospectively investigated in Japanese patients with type 1 or insulin‐treated type 2 diabetes. Materials and Methods A total of 207 participants with type 1 diabetes (mean age 55 years) and 1,396 with insulin‐treated type 2 diabetes (mean age 65 years) from the local diabetes registry were followed for 5 years (follow‐up rate 99%). Severe hypoglycemia was defined as events requiring the assistance of others for recovery from hypoglycemia. Results The incidence of severe hypoglycemia was 9.2 per 100 person‐years in those with type 1 diabetes, and 2.3 per 100 person‐years in those with insulin‐treated type 2 diabetes, respectively. For type 1 diabetes, the risk was significant in those with a history of severe hypoglycemia within the previous year, slow eating and higher serum adiponectin (the highest vs the lowest in quartile hazard ratio 2.36, 95% confidence interval 1.22–4.69). For insulin‐treated type 2 diabetes, the risk included age ≥65 years, history of severe hypoglycemia within the previous year, alcohol consumption ≥60 g/day, larger insulin dose and higher serum adiponectin (the highest vs the lowest in quartile, hazard ratio 2.95, 95% confidence interval 1.22–4.69). For all participants, the incidence of severe hypoglycemia increased along with serum adiponectin (age‐ and sex‐adjusted hazard ratio 1.65 per 1 standard deviation increase of log serum adiponectin, 95% confidence interval 1.45–1.87). Conclusions The incidence of severe hypoglycemia was prospectively determined, and the association between severe hypoglycemia and higher serum adiponectin was observed in Japanese patients with type 1 and insulin‐treated type 2 diabetes.
- Published
- 2020
- Full Text
- View/download PDF
4. Impact of hip fracture on all‐cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry
- Author
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Yuji Komorita, Masanori Iwase, Yasuhiro Idewaki, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai‐Kitamura, Masahito Yoshinari, Ai Murao‐Kimura, Yutaro Oku, Udai Nakamura, and Takanari Kitazono
- Subjects
Death ,Hip fracture ,Type 2 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims/Introduction Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all‐cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end‐stage renal disease (ERSD). Materials and Methods In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow‐up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all‐cause death by logistic regression analysis. Results A total of 309 participants died during follow up. Multivariate‐adjusted odds ratios (ORs) for all‐cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all‐cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all‐cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.
- Published
- 2020
- Full Text
- View/download PDF
5. Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin‐treated type 2 diabetes: The Fukuoka Diabetes Registry
- Author
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Udai Nakamura, Masahito Yoshinari, Hitoshi Ide, Masanori Iwase, Takanari Kitazono, Toshiaki Ohkuma, Hiroki Fujii, Yutaro Oku, Taiki Higashi, and Yuji Komorita
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Type 2 diabetes ,Hypoglycemia ,Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,030212 general & internal medicine ,Prospective Studies ,Registries ,Aged ,Type 1 diabetes ,Adiponectin ,business.industry ,Incidence (epidemiology) ,Incidence ,Hazard ratio ,nutritional and metabolic diseases ,General Medicine ,Articles ,Middle Aged ,medicine.disease ,Prognosis ,RC648-665 ,Clinical Science and Care ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Original Article ,Female ,business ,Biomarkers ,Follow-Up Studies - Abstract
Aims/Introduction The incidence of severe hypoglycemia and its risk factors including an insulin‐sensitizing adipokine, adiponectin, were prospectively investigated in Japanese patients with type 1 or insulin‐treated type 2 diabetes. Materials and Methods A total of 207 participants with type 1 diabetes (mean age 55 years) and 1,396 with insulin‐treated type 2 diabetes (mean age 65 years) from the local diabetes registry were followed for 5 years (follow‐up rate 99%). Severe hypoglycemia was defined as events requiring the assistance of others for recovery from hypoglycemia. Results The incidence of severe hypoglycemia was 9.2 per 100 person‐years in those with type 1 diabetes, and 2.3 per 100 person‐years in those with insulin‐treated type 2 diabetes, respectively. For type 1 diabetes, the risk was significant in those with a history of severe hypoglycemia within the previous year, slow eating and higher serum adiponectin (the highest vs the lowest in quartile hazard ratio 2.36, 95% confidence interval 1.22–4.69). For insulin‐treated type 2 diabetes, the risk included age ≥65 years, history of severe hypoglycemia within the previous year, alcohol consumption ≥60 g/day, larger insulin dose and higher serum adiponectin (the highest vs the lowest in quartile, hazard ratio 2.95, 95% confidence interval 1.22–4.69). For all participants, the incidence of severe hypoglycemia increased along with serum adiponectin (age‐ and sex‐adjusted hazard ratio 1.65 per 1 standard deviation increase of log serum adiponectin, 95% confidence interval 1.45–1.87). Conclusions The incidence of severe hypoglycemia was prospectively determined, and the association between severe hypoglycemia and higher serum adiponectin was observed in Japanese patients with type 1 and insulin‐treated type 2 diabetes., The incidence of severe hypoglycemia was prospectively determined in Japanese patients with type 1 and insulin‐treated type 2 diabetes. The development of severe hypoglycemia was associated with higher serum adiponectin level.
- Published
- 2020
6. Impact of hip fracture on all‐cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry
- Author
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Yutaro Oku, Udai Nakamura, Masanori Iwase, Tamaki Jodai-Kitamura, Ai Murao-Kimura, Yasuhiro Idewaki, Toshiaki Ohkuma, Hitoshi Ide, Masahito Yoshinari, Takanari Kitazono, Hiroki Fujii, and Yuji Komorita
- Subjects
Male ,medicine.medical_specialty ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,Logistic regression ,Diseases of the endocrine glands. Clinical endocrinology ,Hip fracture ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Cause of Death ,Internal Medicine ,Medicine ,Humans ,030212 general & internal medicine ,Registries ,Cause of death ,Aged ,business.industry ,Hip Fractures ,Type 2 Diabetes Mellitus ,General Medicine ,Odds ratio ,Articles ,Middle Aged ,medicine.disease ,Prognosis ,RC648-665 ,Confidence interval ,Survival Rate ,Death ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Kidney Failure, Chronic ,Original Article ,Female ,business ,Follow-Up Studies - Abstract
Aims/Introduction Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all‐cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end‐stage renal disease (ERSD). Materials and Methods In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow‐up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all‐cause death by logistic regression analysis. Results A total of 309 participants died during follow up. Multivariate‐adjusted odds ratios (ORs) for all‐cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all‐cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all‐cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD., Hip fracture is associated with increased mortality in the general population, although few studies have investigated the impact of hip fractures on the risk of death in patients with type 2 diabetes who also have a higher prevalence of fatal diseases, such as cardiovascular disease, renal disease or malignant neoplasia. In this study, the presence of hip fracture was associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of cardiovascular disease and end‐stage renal disease. It should be emphasized that hip fracture is a critical event in the aging population of patients with type 2 diabetes.
- Published
- 2020
7. Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry
- Author
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Hitoshi Ide, Akiko Sumi, Yuji Komorita, Tamaki Jodai-Kitamura, Toshiaki Ohkuma, Udai Nakamura, Masahito Yoshinari, Takanari Kitazono, Masanori Iwase, and Hiroki Fujii
- Subjects
Male ,Pediatrics ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Body Mass Index ,0302 clinical medicine ,Glycemic control ,Japan ,Risk Factors ,030212 general & internal medicine ,Prospective Studies ,Registries ,Child ,Abdominal obesity ,Age at menarche ,Incidence ,Age Factors ,General Medicine ,Articles ,Middle Aged ,Prognosis ,Clinical Science and Care ,Menarche ,Female ,Original Article ,medicine.symptom ,Adult ,medicine.medical_specialty ,Adolescent ,030209 endocrinology & metabolism ,03 medical and health sciences ,Young Adult ,Type 2 diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Obesity ,Glycemic ,Aged ,Retrospective Studies ,business.industry ,Type 2 Diabetes Mellitus ,Odds ratio ,medicine.disease ,Hypoglycemia ,Diabetes Mellitus, Type 2 ,Hyperglycemia ,business ,Body mass index ,Biomarkers ,Follow-Up Studies - Abstract
Aims/Introduction A younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early‐onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. The present study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes. Materials and Methods A total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11, 12, 13, 14 and ≥15 years). A retrospective cohort study examined the association of menarcheal age with adiposity and hemoglobin A1c. Results Age at menarche was inversely associated with body mass index (BMI) and abdominal circumference (P < 0.001). Each 1‐year decrease in age at menarche was associated with a 0.25‐kg/m2 and 0.6‐cm increase in BMI and abdominal circumference, respectively, using a multivariate‐adjusted model. Odds ratios for obesity and abdominal obesity significantly increased in participants with age at menarche ≤11 years after multivariable adjustments when age at menarche of 13 years was used as the reference (odds ratio 1.95, 95% CI 1.33–2.88, odds ratio 1.95, 95% CI 1.32–2.87, respectively). Younger age at menarche was significantly associated with higher hemoglobin A1c (P < 0.001); however, the association was not statistically significant after adjusting for BMI. Conclusions Age at menarche of ≤11 years was associated with obesity after adjusting for confounding factors, and poor glycemic control associated with high BMI in type 2 diabetes. Age at menarche should be considered during clinical assessments.
- Published
- 2017
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