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Your search keyword '"Ma, Ze"' showing total 6 results
Start Over Author "Ma, Ze" Journal journal of diabetes research
6 results on '"Ma, Ze"'

1. Association between eNOS 4b/a Polymorphism and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Meta-Analysis

Author

Ma, Ze-jun, Chen, Rui, Ren, Hui-Zhu, Guo, Xin, Guo, Jun, and Chen, Li-ming

Subjects
Article Subject
Abstract

Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases and 3, 410 controls were enrolled by searching the databases of Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Chinese Wanfang Database. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The main analysis indicated no significant association between eNOS-4b/a polymorphism and the risk of DR in overall population [allelic model: OR=0.94 (0.79–1.11); additive model: OR=0.91 (0.73–1.14); recessive model: OR=1.01 (0.81–1.25); dominant model: OR=0.91 (0.75–1.09)]. Subgroup analysis by ethnicity also indicated no significant association. In conclusion, the current meta-analysis did not observe any association between the polymorphism of eNOS 4b/a and the risk of DR among type 2 diabetic subjects. However, larger well-designed studies are required to confirm this finding.

Published
2014
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6. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis.

Author

Zhang, Xiao-na, Ma, Ze-jun, Wang, Ying, Li, Yu-zhu, Sun, Bei, Guo, Xin, Pan, Cong-qing, and Chen, Li-ming

Subjects
*CHINESE medicine formulae, receipts, prescriptions, *WOUND healing, *PEOPLE with diabetes, *IMMUNOLOGY of inflammation, *NEOVASCULARIZATION, *STREPTOZOTOCIN, *WOUNDS & injuries, *THERAPEUTICS
Abstract

Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments. Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been prescribed for nearly 400 years in China and shows good efficacy in promoting healing. In this study, we explored the effect of TLXDS on healing of diabetic wounds and investigated underlying mechanisms. Four weeks after intravenous injection of streptozotocin, two full-thickness excisional wounds were created with a 10 mm diameter sterile biopsy punch on the back of rats. The ethanol extract of TLXDS was given once daily by oral gavage. Wound area, histological change, inflammation, angiogenesis, and collagen synthesis were evaluated. TLXDS treatment significantly accelerated healing of diabetic rats and improved the healing quality. These effects were associated with reduced neutrophil infiltration and macrophage accumulation, enhanced angiogenesis, and increased collagen deposition. This study shows that TLXDS improves diabetes-impaired wound healing. [ABSTRACT FROM AUTHOR]

Published
2015
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