1. Development and application of an osthole microemulsion hydrogel for external drug evaluation
- Author
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Hui-Ning Wang, Jing Liu, Li-Qun Yang, Zi-Yi Zhai, Jing You, Shu Meng, Bing Li, Xiao-Wei Zhang, Jun-Chao Fan, Fang-Ming Yin, Jing-Jing Li, Ying-Kai Ning, and Zaixing Chen
- Subjects
Materials science ,integumentary system ,Pharmaceutical Science ,02 engineering and technology ,021001 nanoscience & nanotechnology ,030226 pharmacology & pharmacy ,03 medical and health sciences ,0302 clinical medicine ,Distilled water ,Molecular stability ,Drug delivery ,Zeta potential ,Microemulsion ,Particle size ,Solubility ,0210 nano-technology ,Transdermal ,Nuclear chemistry - Abstract
The aim of the study is to provide a new type of drug delivery, combining the advantages of a microemulsion with the transdermal administration of osthole. Appropriate oil phases, surfactants, and cosurfactants were screened by their solubility, transmittance, etc. The appropriate microemulsion ratio formula was selected by measuring the area of the formed microemulsion region from the pseudoternary phase diagram among the different proportions. After measuring the pH, zeta potential, particle size, etc., a 2% osthole drug-containing microemulsion was prepared, and transdermal experiments were performed using a Franz cell. To select a microemulsion formula with high stability and a high skin transmittance rate, 65% distilled water (w/w) was embedded into the microemulsion (7% IPM (w/w), 14% Tween 80 (w/w) and 14% Labrasol (w/w)), and the microemulsion gel was made with different proportions of carbomer. The structure, water content and molecular stability of the microemulsion gels were measured by TEM and DSC. Transdermal experiments were then performed using Franz cells, and these microemulsion gels were applied to determine the subcutaneous residual amounts and optimal skin penetration microemulsion formulations. Thereby, the best microemulsion gel formulation was selected.
- Published
- 2019